Henry Kissinger issued FINAL WARNING that “superhuman” entities would control the world, not We the People A new book from Trilateral Commission members Eric Schmidt, Google's CEO, and the late Henry Kissinger warns that in the not-too-distant future, the entire world will be controlled by "superhuman" artificial intelligence (AI) robots without emotions, compassion or a soul. Called Genesis, the book is a blueprint for the godless future that Schmidt and Kissinger envision, one without any acknowledgement or inclusion of God as Creator. Instead, Schmidt and Kissinger, the latter of which is now receiving his eternal consequences in the afterlife, want the world to be godless and robotic so they and their spawn can remain on the proverbial throne forever. The Trilateral Commission has been architecting this dystopian future for many decades, it turns out. And now its members want the general public to know about it and to prepare accordingly. The plan is to have AI actually produce fake "superhuman" people, though they will not actually be people but rather human-like automatons that are completely obedient to the powers that be (TPTB). The reason they are fessing up at this time is probably because they no longer fear that their plans will be derailed by We the People. "Kissinger's co-authors, former Google CEO Eric Schmidt and longtime Microsoft senior executive Craig Mundie, finished the combined work after Kissinger's death," writes Ryan Lovelace of The Washington Times, which obtained an advance copy of the book. "Mr. Schmidt and Mr. Mundie wrote they were among the last people to speak with Kissinger and sought to honor his dying request to finish the manuscript." "The authors offer a bracing message, warning that AI tools have already started outpacing human capabilities so people might need to consider biologically engineering themselves to ensure they are not rendered inferior or wiped out by advanced machines." (Related: Just a few weeks before he died at the ripe old age of 100, Kissinger was complaining about all the migrants he helped usher into Europe because suddenly they were protesting for Palestine.) Humans becoming obsolete Kissinger's perspective sees humans as irrelevant or obsolete, thanks to the rise of AI and everything technological that surrounds it. An entire section of his book is devoted to the thesis that humans need to start thinking now about "trying to navigate our role when we will no longer be the only or even the principal actors on our planet." "Biological engineering efforts designed for tighter human fusion with machines are already underway." What Kissinger et al. mean by this is that in the coming days, new brain-computer interfaces will be installed into people's bodies to turn them into human-AI hybrid machines. Tesla's Elon Musk, who is now part of the incoming Trump administration's "DOGE" plan for cleaning up Washington, is at the forefront of creating these brain-computer interfaces with Neuralink. "Such interfaces allow for a direct link between the brain's electrical signals and a device that processes them to accomplish a given task, such as controlling a battleship," Lovelace explains about how it works. Kissinger et al. are also eager to see a new world order filled with genetically "superior" people whose bodies have been specifically engineered to work better with the latest emerging AI tools. When that happens, the human race will "split into multiple lines, some infinitely more powerful than others," the book says. "Altering the genetic code of some humans to become superhuman carries with it other moral and evolutionary risks," the book's authors further write. "If AI is responsible for the augmentation of human mental capacity, it could create in humanity a simultaneous biological and psychological reliance on 'foreign' intelligence." More related news about the dystopian future (and present) the globalists are architecting can be found at Globalism.news. Sources for this article include: Technocracy.news NaturalNews.com http://www.naturalnews.com/2024-11-25-henry-kissinger-final-warning-superhuman-entities-control-world.html

Curcumin, found in turmeric, appears to raise endogenous glutathione production in the brain, a major antioxidant defense system. The study investigated the mechanisms through which fluoride induces severe neurodegenerative changes in the mammalian brain, particularly in cells of the hippocampus and cerebral cortex. Follow: Quantum Medicine ✅️

Now they're going for microRNAs What are the implications of this? Jessica Rose MicroRNAs (miRNAs) are small, non-coding RNA regulatory molecules that play critical roles in post-transcriptional regulation of gene expression. They bind complementary sequences in messenger RNA thus messing with translation and protein production. miRNAs are approximately 21-23 nucleotides in length and are found in plants, animals, and some viruses. Venice.ai made this image when prompted with ‘microRNA’ miRNAs have been implicated in almost everything biology including development, differentiation and stress responses. They also play roles in the regulation of cell cycle progression, apoptosis, and metabolism, so they’re pretty important for little dudes considering they don’t code for anything. Isn’t it ironic that they are coded but don’t code? They: effect. Kind of like a piece of driftwood in the way of clean line of a wave - in its presence, can’t surf the line. I asked Venice.ai to draw a surfer on a clean wave with a piece of driftwood in the way and it gave me this. But I digress. Pretty disturbing there Venice. Dysregulation of miRNA expression can be associated with numerous diseases, including cancer, cardiovascular disease, neurological disorders, and metabolic disorders. This is the reason why miRNAs are emerging as ‘promising therapeutic targets’ for the treatment of disease, whereby some are exploring the potential of miRNA-based therapies, such as miRNA mimetics and antagomirs, to modulate miRNA expression and “restore normal gene expression patterns” in disease. The other day, Victor Ambros, PhD, professor of program in molecular medicine at the University of Massachusetts Chan Medical School, and Gary Ruvkun, PhD, professor of genetics at Harvard Medical School received the 2024 Nobel Prize for discovery of microRNA. You can read about that here. I have been in this ‘game’ long enough to see where this is going and I don’t like it. Why can’t hubristic men stop trying to play God? Cancer, just as one grant-sexy example, is a metabolic disorder and we don’t need to mess with genetic factors to ‘fix it’. Don’t get me wrong; it’s not that I have anything against these scientists and researchers - I am sure they are excellent and have benevolent intentions - but it is the misuse and abuse of their discoveries by bureaucrats and business men that bugs me, and quite frankly, that I find simply dangerous. An article entitled: “MicroRNAs from edible plants reach the human gastrointestinal tract and may act as potential regulators of gene expression” was also published on April 25, 2024, that describes the interaction of plant microRNAs and the human gut (microbiome). This subject matter was also published here in 2018. Basically they describe the impact and importance of these RNA binding factors to affect health, and in the latter article, they promote the idea of increasing bioavailability of plant miRNAs in animals through intervention. In addition, it has been unveiled that a short plant-based dietary intervention can increase the abundance of exogenous miRNAs in the gut. Therefore, significant effects of plant miRNAs on human physiology could potentially be displayed thought the interaction with gut cells (i.e. enterocytes) and bacteria. The authors claim that there is a “need to develop novel strategies to improve the bioavailability of plant miRNAs beyond the gut” using nanocarriers for modulation of important biological pathways. I would argue that there is no such need. At all. There is certainly a need to explore the realm of our existence and co-existence with other living creatures - including bacteria - but this ‘application-to-big-pharma-to-make-money’ thing has got to get a grip. Or rather, we have got to get a grip on it. The absconsion of functional mechanisms and biology itself that promote ‘normal functioning’ of complex beings is becoming a huge problem in the realm of biotechnology, genetics, therapeutics, all …ics. Instead of prevention strategies and focused solution-driven strategies to get people ‘eased’ as opposed to ‘diseased’, we are focused on bandaid solutions that inevitably promote more and prolonged disease. This is so insincere! Doctors should be taught to address core problems - to diagnose the actual cause of disease - in order to not only prevent disease but to reverse it! It is becoming the status quo that instead of pharmaceuticals with half-lives, we are being bombarded with gene-based therapeutics and prodrugs wrapped in cationic lipid nanobubbles laced with polyethylene glycol for presumptive quick fixes without even knowing what the source of a preventable/treatable medical condition or disease is. This was what the COVID con was most useful for to those seeking to profit from gene-based therapeutics - to normalize the genetic-based LNP platform so that it is never even questioned. The modified mRNA-LNP platform is now even referred to by many as “conventional”, after what can only be described by anyone paying attention to the peer-reviewed literature as 3 failed years. We don’t need to stop giving accolades for scientific discoveries, but we certainly need to stop letting bureaucrats and industry executives make decisions about our health. Seriously guys. When speaking of self-amplifying RNA technology based on viral components stolen from alphaviruses (think recombination), modified mRNA that leads to frameshifting and DNA contamination, or microRNA applications, we need to bloody stop and reconsider the data collected from the recent mass injection roll-out. The data is not painting a glowing picture of this platform or gene-based LNP therapies in general. We must have answers to the most basic questions in science such as: How does the intercellular rate-limiting step of endosomal release of nucleotide-based foreign entities affect cell health in general? What are the effects of dsRNA? What are the effects of R-loop accumulation potentially introduced by the modified mRNA-LNP COVID-19 injectable products? Is it possible to use the plasmid/E. coli upscaling system in the context of N1-pseudoUs without introducing DNA to the final product due to problems associated with RNA:DNA hybrids? Is the risk of recombination with endogenous RNAs going to be assessed in the context of self-amplifying RNAs? Which cells are transfected in the context of LNP-based genetic prodrugs? Is there a way to quantify a dose in vivo (in the human being context)? It’s unreal to me that most doctors and scientists don’t even realize that these questions need to be asked let alone the answers to them. And since this is the case, how on Earth are bureaucrats making ‘health policy’ decisions meant to be informed as to the potential threats to our health on a species level? Feel free to comment. 1 Bhaskaran M, Mohan M. MicroRNAs: history, biogenesis, and their evolving role in animal development and disease. Vet Pathol. 2014 Jul;51(4):759-74. doi: 10.1177/0300985813502820. Epub 2013 Sep 17. PMID: 24045890; PMCID: PMC4013251 2 O'Brien J, Hayder H, Zayed Y, Peng C. Overview of MicroRNA Biogenesis, Mechanisms of Actions, and Circulation. Front Endocrinol (Lausanne). 2018 Aug 3;9:402. doi: 10.3389/fendo.2018.00402. PMID: 30123182; PMCID: PMC6085463 3 Macfarlane LA, Murphy PR. MicroRNA: Biogenesis, Function and Role in Cancer. Curr Genomics. 2010 Nov;11(7):537-61. doi: 10.2174/138920210793175895. PMID: 21532838; PMCID: PMC3048316 4 Ardekani AM, Naeini MM. The Role of MicroRNAs in Human Diseases. Avicenna J Med Biotechnol. 2010 Oct;2(4):161-79. PMID: 23407304; PMCID: PMC3558168 5 Suzuki HI. Roles of MicroRNAs in Disease Biology. JMA J. 2023 Apr 14;6(2):104-113. doi: 10.31662/jmaj.2023-0009. Epub 2023 Mar 24. PMID: 37179717; PMCID: PMC10169270 6 Ying SY, Chang DC, Lin SL. The microRNA (miRNA): overview of the RNA genes that modulate gene function. Mol Biotechnol. 2008 Mar;38(3):257-68. doi: 10.1007/s12033-007-9013-8. Epub 2007 Nov 13. PMID: 17999201; PMCID: PMC7091389. 7 Díez-Sainz, E., Milagro, F.I., Aranaz, P. et al. MicroRNAs from edible plants reach the human gastrointestinal tract and may act as potential regulators of gene expression. J Physiol Biochem (2024). https://doi.org/10.1007/s13105-024-01023-0 8 Li, Z., Xu, R. & Li, N. MicroRNAs from plants to animals, do they define a new messenger for communication?. Nutr Metab (Lond) 15, 68 (2018). https://doi.org/10.1186/s12986-018-0305-8 https://open.substack.com/pub/jessicar/p/now-theyre-going-for-micrornas

Zika Virus or Roundup Herbicide The Cause of Microcephaly? Zika Virus or Glyphosate Exposure Causing Microcephaly Originally published on jeffreydachmd.com. What's causing microcephaly? It might not be what the media is telling you... Is It Zika Virus or Glyphosate Exposure ? The news media has been reporting the Zika virus as the cause of microcephaly. The story originated in a Monsanto chemical industry press release dated Feb 17, 2016 which was then copied over the news media. The Zika virus was discovered in Uganda in 1947, and there have been no reports of microcephaly in Uganda. A US news article says, according to Associated Press journalists who visited the Zika Forest in Uganda on Feb 1, 2016, local officials have no concern about the Zika virus.(24) New England Journal Reports A recent study published in the New England Journal of Medicine reported Zika Virus surveillance in Colombia.(80-81) Of 50 babies reported with microcephaly, only four (8 %) had laboratory evidence of congenital Zika virus infection on RT-PCR. The other 46 cases (92 %) were due to other causes. Of 1850 pregnant women reported infected with Zika virus, no babies were born with microcephaly. The authors state: (80-81) “maternal infection with the Zika virus during the third trimester of pregnancy is not linked to structural abnormalities in the fetus.” Since 92% of microcephaly babies are not caused by maternal Zika virus, perhaps we should be looking for other preventable causes. Dr Yaneer Bar-Yam reviewed this same data from the Colombia surveillance study After reviewing this data, Dr Yaneer Bar-Yam concluded in his own report entitled: “Is Zika the cause of Microcephaly?”that there is no direct link between zika virus and microcephaly, and he proposed pesticide exposure (pyriproxyfen) in the drinking water as an alternative explanation(99): “This (data) would seem to rule out Zika as a cause of microcephaly. This gives a consistent interpretation that there is no direct link between Zika and microcephaly except for random co-occurrence.”….”An alternative cause of microcephaly in Brazil could be the pesticide pyriproxyfen, which is cross-reactive with retinoic acid, which causes microcephaly, and is being used in drinking water.”(99) Dr Tiago Baptista Questions Zika as Sole Cause of Microcephaly Maternal viral infection with rubella or cytomegalovirus have been known to cause fetal malformation and fetal demise. There is no doubt that viral illness during pregnancy is best avoided.(47-55) However, Dr Tiago Baptista in a 2016 BMJ article questions “whether the surge in reported cases of microcephaly is entirely due to Zika virus infection“(55) He says: “The risk of microcephaly after maternal infection is estimated at roughly one in 100 women… This is a relatively low risk compared with other causal infections such as cytomegalovirus.”(55) A Distraction From the Real Cause- Exposure to Glyphosate Causes Microcephaly and other Congenital Anomalies I suggest that the Zika virus is merely a distraction away from the real cause, agrichemical exposure from Monsanto’s Round-Up Herbicide, glyphosate, (1-4) Dr Alejandra Paganelli reported in 2010 that “Glyphosate-based herbicides produce teratogenic effects on vertebrates by impairing retinoic acid signaling.” (8) Dr Paganelli concludes: “(congenital malformations) “produced by Glyphosate Based Herbicides are mainly a consequence of the increase of endogenous retinoid activity. ” (8) Dr Sylvia Lopez In 2012, Dr Silvia L. Lopez reviewed the effects of agricultural chemicals, glyphosate based herbicides, in human and animal models.(9) She says: “It is very well known that acute or chronic increase of retinoic acid (RA) levels leads to teratogenic effects during human pregnancy and in experimental models. The characteristic features displayed by Retinoic Acid embryopathy in humans include brain abnormalities such as microcephaly, microphtalmia, and impairment of hindbrain development; abnormal external and middle ears (microtia or anotia), mandibular and midfacial underdevelopment, and cleft palate.” (9) Note: Retinoic Acid is Vitamin A Derivative. Dr Benitez-Leite Dr Benitez-Leite reported 52 cases of malformations in babies born of women exposed to agricultural chemicals. The congenital malformations observed include anencephaly, microcephaly, facial defects, myelomeningocele, cleft palate, ear malformations, polydactily, syndactily all consistent with the well-known and expected syndrome caused by upregulation of the Retinoic Acid pathway.(10) Left image Monsanto’s Roundup herbicide contains glyphosate. Upregulation of Retinoic Acid Pathway A number of reports have linked arial spraying with the mosquito larvicide pyriproxyfen to birth defects such as microcephaly in the crop sprayed towns of Northeast Brazil.(106-108) Pyriproxyfen disrupts retinoic acid (vitramin A) signalling, a known mechanism for microcephaly (106-108) In 1995, Dr Kenneth Rothman reported in NEJM that High Vitamin A Intake causes birth defects. (109) Increasing Anencephaly in Yakima Valley in Washington State Another mechanism is glyphosate disruption of folate metabolsm as discussed below in the Yakima Washington State case. (35-37) Over three years from 2010 to 2013, the Washington State Department of Health reported an unusual increase in anencephalic babies born in Yakima, Benton and Franklin counties, four times higher than the national average. (33-34) Anencephaply, microcephaly and spina bifida are all related disorders of neural tube closure associated with maternal folate deficiency. Maternal folate supplementation is preventive. Maternal folate supplementation in Yakima was not at issue, as this was similar to the national average. Barbara Peterson, in Farm Wars, makes a compelling case for glyphosate exposure as the cause, since the Yakima river running through the affected counties had been heavily treated with glyphosate for weed control during that time period.(29) Left image Yakima River Washington State. Glyphosate Disrupts Folate Metabolism Glyphosate disruption of folate metabolism is discussed by Stephanie Seneff in her May 2016 article on Weston Price.(35) Glyphosate acts as an antibiotic, killing friendly bacteria by blocking the Shikimate pathway. These friendly bacterial are also involved in bacterial conversion of folic acid to methyl folate, its active form. Maternal methylfolate deficiency is associated with neural tube defects in the developing embryo.(85-87) Glyphosate Disrupts Glycine Metabolism Stephanie Seneff’s article then discusses how glyphosate disrupts glycine decarboxylase metabolism, known to cause neural tube defects in animal studies and humans.(36-37) Glyphosate is the amino acid glycine with an added phosphate group, so glyphosate may readily displace glycine in various biochemical reactions. Glyphosate disrupts glycine decarboxylase by displacing glycine as a substrate. In addition, glyphosate replaces glycine at insertion sites in amino acid chains during protein synthesis, producing defective enzymes (35). Glyphosate is basically the amino acid, glycine with a phosphate group added on to it. Glyphosate is a Patented Antimicrobial, Anti-Folate Drug Glyphosate is actually patented as an anti-microbial drug. (83,84) Glyphosate serves as an anti-folate agent working in synergy with other anti-folate drugs.(58,61) Other anti-folate drugs in common use include the urinary tract antibiotic, Bactrim (trimethoprim/sulfamethoxazole) the rheumatology drug, methotrexate, and the anti-seizure drug Dilantin (phentoin). Maternal exposure to anti-folate drugs such as methotrexate Bactrim and Dilantin increase risk of neural tube defects in the fetus up to six-fold. (85-87) Maternal folate supplementation has been shown to reduce incidence of fetal neural tube defects (NTD), and folic acid fortification in food supply was mandated in 1998. (85-87)(100-103) Glyphosate Inhibits the Shikimate Pathway Glyphosate’s known mode of action is inhibition of the shikimate pathway in plants, fungi, bacteria and parasites.(58) Glyphosate blocks the pathway which produces Folate, Ubiquinone (Co-Q10), Vitamin K, and the aromatic amino acids tryptophan, phenylalanine, and tyrosine. Government Regulators Deemed Glyphosate Safe for Humans Government regulators deemed glyphosate safe for us humans because we lack the shikimate pathway. They forgot to consider that we humans depend on the shikimate pathway in plants and gut bacteria for our folate (vitamin B9), to prevents neural tube defects. If your lunch salad comes from an agricultural field treated with glyphosate which blocks the plant’s ability to synthesize folate, how much folate are you getting in your meal ? If you are ingesting glyphosate in your food, blocking your gut bacteria from synthesing folate, how soon will you be rendered folate deficient? Dr Bekaert says in 2008, “Humans cannot synthesize folates (vitamin B9) and thus have to rely on plant food supplying these essential vitamins.“(104) Dr Craig Roberts suggests that Glyphosate may serve as anti-folate, anti-parasitic drug ,He says:(58) ” it is likely that the shikimate pathway is important for supply of folate precursors in this parasite….inhibitors of EPSP synthase (such as glyphosate) can act in synergy with conventional antifolates and may be a useful addition to the agents used against apicomplexan parasites.”(58) A quote from a University of Chicago Press Release 1998 (61) explains that Glyphosate blocks production of folate: “Effective new ways to inhibit parasites that cause malaria, toxoplasmosis and cryptosporidiosis” June 25, 1998.(61) “Dr. McLeod’s team showed that glyphosate, …could block the production of folate, inhibiting parasite growth and survival. Glyphosate proved effective against malaria strains that were resistant to an anti-malarial medicine, pyrimethamine, which interrupts folate processing at a different point. To confirm the finding, they demonstrated that these folate-starved parasites could be rescued, in the test tube, by giving them folate.”(61) Brazil Annual Pesticide Sales Surpasses the US Left Image courtesy of Reuters. Brazil sales of herbicide (glyphosate) exceeds that of US.(81) According to Paulo Prada in her 2015 article, Brazil has a huge appetite for pesticides and herbicides, surpassing annual sales in the US.(81) Poalo Prado explains that in Northeast Brazil, irrigation canals were built, transforming previously arid land into fertile farm land. These open air irrigation canals are heavily contaminated with herbicides and pesticides liberally applied to the crop fields. Life is primitive for the agricultural workers who live without piped in water for their dwellings. The local workers use the open air irrigation canals for their drinking water, thus are heavily exposed to herbicide and pesticide runoff. House Passes 1.1 Billion Zika Virus Bill. Methyl-Folate is Cheaper. Instead of spending 1.1 Billion dollars on a “controversial” Zika Virus Bill, I have a better idea for prevention of microcephaly and neural tube defects. (90) Suppose we instead allocate 100 million dollars to give out free methyl-folate tablets to all pregnant women exposed to glyphosate here in the US, and in Brazil. That would solve the problem at a fraction of the cost, saving a Billion Dollars.(90) 53 Countries Have Mandatory Flour Fortification with Folate Folate fortification of flour for prevention of neural tube defects (anencephaly, microcephaly, spina bifida etc.) is mandated in 53 countries. Fortification of flour with folic acid was mandated in the US in 1998, the most successful public health measure in history, with reduction of neural tube defects by 36%.(100-103) In 2009, Dr Oakley declared this success story a “modern miracle of epidemiology”.(103) Study Blood Folate Levels in North East Brazil Why not allocate research funds to study blood folate levels in women in Northeast Brazil at high risk for having babies with neural tube defects? This was done here in the US before and after starting folate fortification in 1998, showing reduction incidence of neural tube defects by 36%.(101) Folate deficiency (blood folate levels less than 3 ng/ml)) decreased from 21% to less than 1% of the population. (101) In Australia, mandatory fortification of bread with folate and iodine was introduced in 2009, resulting in a 50-80 per cent reduction in neural tube defects in at-risk indigenous women and teenagers.(100-112) Reducing Microcephaly in Brazil with Folate Fortification Studies done in Brazil shows folate deficiency is severe, affecting 94% among the poor.(113) Folate fortification of flour in three south American countries (Brazil, Argentina, Chile) resulted in significant reduction in 52 different fetal anomalies including reduction in microcephaly and anencephaly.(114) Currently all South American countries except Venezuala have mandatory folate fortification legislation.(115) In populations using folate fortification there have been decreases in neural tube defects from 30-50%.(115) How is Such an Error Possible ? You might ask the obvious question, “how is such an error in thinking possible” that the government would waste a billion dollars on Zika instead of Folate Fortification? This is called CrimeStop or “Protective Stupidity“, aptly described in 1984 by George Orwell (91): “The mind should develop a blind spot whenever a dangerous thought presented itself….Crimestop, they called it in Newspeak….the Party says the earth is flat’, ‘the party says that ice is heavier than water’—and trained himself in not seeing or not understanding the arguments that contradicted them.” “Crimestop means the faculty of stopping short, as though by instinct, at the threshold of any dangerous thought. It includes the power of not grasping analogies, of failing to perceive logical errors, of misunderstanding the simplest arguments…”…”Crimestop, in short, means protective stupidity.”(91) Using Fear and Smear Tactics to Distract Attention from Monsanto This article in the Huffington Post Feb 16 is typical of the Monsanto tactics to distract attention away from Roundup glyphosate as the cause of the birth defects in agricultural workers in Brazil; A Viral Story Links The Zika Crisis To Monsanto. Don’t Believe It. by Anna Almendrala Senior Healthy Living Editor Huffington Post. Anna’s piece is pure Monsanto propaganda masquerading as journalism, don’t believe a word of it. If you trust anything Monsanto says, then I have a bridge to sell you. Monsanto has known for decades that Glyphosate causes birth defects, see this report: Roundup and birth defects. Is the public being kept in the dark ? by Michael Antoniou Earth Open Source June 2011 Search Google Scholar for articles with key words “microcephaly pesticide“ : you will see 2160 articles pop up. Glyphosate is “Probably Carcinogenic to Humans” A number of studies show glyphosate exposure doubles the incidence of Non-Hodgkins Lymphoma.(92) As reported in Lancet Oncology by Dr Kathryn Guyton, on March, 2015, 17 experts from 11 countries met in Lyon France and classified glyphosate as “probably carcinogenic to humans” (89) Zika Distraction from Glyphosate – The Elephant in the Room Certainly, maternal viral illness with Rubella, (CMV) cytomegalovirus and Zika are all risk factors for fetal demise, and fetal malformations, and are best avoided.(93-95) However, the Zika Virus is a distraction from the real cause of the problem, massive glyphosate exposure to pregnant agricultural workers in Brazil. Glyphosate is a patented anti-folate drug, Anti-folate drugs are known to cause microcephaly and neural tube defects in animals and humans. Professor Don Huber, GMO Food and Glyphosate Increased incidence of birth defects in the population caused by exposure to the anti-folate agent, glyphosate is only the “tip of the iceberg”. The adverse health consequences of GMO food and glyphosate contamination of our food and water supply are much more extensive as outlined in a series of articles posted on the Stephanie Seneff home page. Here is a quote from Professor Don M. Huber:(88) from his document GMO Failed Promises Flawed Science Serious Health Safety Issue ” Future historians may well look back upon our time and write, not about how many pounds of pesticides we did or did not apply, but about how willing we are to sacrifice our children and jeopardize future generations for this massive experiment we call genetic engineering that is based on failed promises and flawed science, just to benefit the bottom line of a commercial enterprise.” Dr. Don M. Huber Link to this article: http://wp.me/p3gFbV-3En Jeffrey Dach MD 7450 Griffin Road Suite 190 Davie, Fl 33314 954-792-4663 Articles with related interest: Dont Ask for HIV Test Ask For Glyphosate Test Curing Autism with Antibiotics Berberine Antdote for an Epidemic References For references, please view original publication.

Zika Virus or Roundup Herbicide The Cause of Microcephaly? Zika Virus or Glyphosate Exposure Causing Microcephaly Originally published on jeffreydachmd.com. What's causing microcephaly? It might not be what the media is telling you... Is It Zika Virus or Glyphosate Exposure ? The news media has been reporting the Zika virus as the cause of microcephaly. The story originated in a Monsanto chemical industry press release dated Feb 17, 2016 which was then copied over the news media. The Zika virus was discovered in Uganda in 1947, and there have been no reports of microcephaly in Uganda. A US news article says, according to Associated Press journalists who visited the Zika Forest in Uganda on Feb 1, 2016, local officials have no concern about the Zika virus.(24) New England Journal Reports A recent study published in the New England Journal of Medicine reported Zika Virus surveillance in Colombia.(80-81) Of 50 babies reported with microcephaly, only four (8 %) had laboratory evidence of congenital Zika virus infection on RT-PCR. The other 46 cases (92 %) were due to other causes. Of 1850 pregnant women reported infected with Zika virus, no babies were born with microcephaly. The authors state: (80-81) “maternal infection with the Zika virus during the third trimester of pregnancy is not linked to structural abnormalities in the fetus.” Since 92% of microcephaly babies are not caused by maternal Zika virus, perhaps we should be looking for other preventable causes. Dr Yaneer Bar-Yam reviewed this same data from the Colombia surveillance study After reviewing this data, Dr Yaneer Bar-Yam concluded in his own report entitled: “Is Zika the cause of Microcephaly?”that there is no direct link between zika virus and microcephaly, and he proposed pesticide exposure (pyriproxyfen) in the drinking water as an alternative explanation(99): “This (data) would seem to rule out Zika as a cause of microcephaly. This gives a consistent interpretation that there is no direct link between Zika and microcephaly except for random co-occurrence.”….”An alternative cause of microcephaly in Brazil could be the pesticide pyriproxyfen, which is cross-reactive with retinoic acid, which causes microcephaly, and is being used in drinking water.”(99) Dr Tiago Baptista Questions Zika as Sole Cause of Microcephaly Maternal viral infection with rubella or cytomegalovirus have been known to cause fetal malformation and fetal demise. There is no doubt that viral illness during pregnancy is best avoided.(47-55) However, Dr Tiago Baptista in a 2016 BMJ article questions “whether the surge in reported cases of microcephaly is entirely due to Zika virus infection“(55) He says: “The risk of microcephaly after maternal infection is estimated at roughly one in 100 women… This is a relatively low risk compared with other causal infections such as cytomegalovirus.”(55) A Distraction From the Real Cause- Exposure to Glyphosate Causes Microcephaly and other Congenital Anomalies I suggest that the Zika virus is merely a distraction away from the real cause, agrichemical exposure from Monsanto’s Round-Up Herbicide, glyphosate, (1-4) Dr Alejandra Paganelli reported in 2010 that “Glyphosate-based herbicides produce teratogenic effects on vertebrates by impairing retinoic acid signaling.” (8) Dr Paganelli concludes: “(congenital malformations) “produced by Glyphosate Based Herbicides are mainly a consequence of the increase of endogenous retinoid activity. ” (8) Dr Sylvia Lopez In 2012, Dr Silvia L. Lopez reviewed the effects of agricultural chemicals, glyphosate based herbicides, in human and animal models.(9) She says: “It is very well known that acute or chronic increase of retinoic acid (RA) levels leads to teratogenic effects during human pregnancy and in experimental models. The characteristic features displayed by Retinoic Acid embryopathy in humans include brain abnormalities such as microcephaly, microphtalmia, and impairment of hindbrain development; abnormal external and middle ears (microtia or anotia), mandibular and midfacial underdevelopment, and cleft palate.” (9) Note: Retinoic Acid is Vitamin A Derivative. Dr Benitez-Leite Dr Benitez-Leite reported 52 cases of malformations in babies born of women exposed to agricultural chemicals. The congenital malformations observed include anencephaly, microcephaly, facial defects, myelomeningocele, cleft palate, ear malformations, polydactily, syndactily all consistent with the well-known and expected syndrome caused by upregulation of the Retinoic Acid pathway.(10) Left image Monsanto’s Roundup herbicide contains glyphosate. Upregulation of Retinoic Acid Pathway A number of reports have linked arial spraying with the mosquito larvicide pyriproxyfen to birth defects such as microcephaly in the crop sprayed towns of Northeast Brazil.(106-108) Pyriproxyfen disrupts retinoic acid (vitramin A) signalling, a known mechanism for microcephaly (106-108) In 1995, Dr Kenneth Rothman reported in NEJM that High Vitamin A Intake causes birth defects. (109) Increasing Anencephaly in Yakima Valley in Washington State Another mechanism is glyphosate disruption of folate metabolsm as discussed below in the Yakima Washington State case. (35-37) Over three years from 2010 to 2013, the Washington State Department of Health reported an unusual increase in anencephalic babies born in Yakima, Benton and Franklin counties, four times higher than the national average. (33-34) Anencephaply, microcephaly and spina bifida are all related disorders of neural tube closure associated with maternal folate deficiency. Maternal folate supplementation is preventive. Maternal folate supplementation in Yakima was not at issue, as this was similar to the national average. Barbara Peterson, in Farm Wars, makes a compelling case for glyphosate exposure as the cause, since the Yakima river running through the affected counties had been heavily treated with glyphosate for weed control during that time period.(29) Left image Yakima River Washington State. Glyphosate Disrupts Folate Metabolism Glyphosate disruption of folate metabolism is discussed by Stephanie Seneff in her May 2016 article on Weston Price.(35) Glyphosate acts as an antibiotic, killing friendly bacteria by blocking the Shikimate pathway. These friendly bacterial are also involved in bacterial conversion of folic acid to methyl folate, its active form. Maternal methylfolate deficiency is associated with neural tube defects in the developing embryo.(85-87) Glyphosate Disrupts Glycine Metabolism Stephanie Seneff’s article then discusses how glyphosate disrupts glycine decarboxylase metabolism, known to cause neural tube defects in animal studies and humans.(36-37) Glyphosate is the amino acid glycine with an added phosphate group, so glyphosate may readily displace glycine in various biochemical reactions. Glyphosate disrupts glycine decarboxylase by displacing glycine as a substrate. In addition, glyphosate replaces glycine at insertion sites in amino acid chains during protein synthesis, producing defective enzymes (35). Glyphosate is basically the amino acid, glycine with a phosphate group added on to it. Glyphosate is a Patented Antimicrobial, Anti-Folate Drug Glyphosate is actually patented as an anti-microbial drug. (83,84) Glyphosate serves as an anti-folate agent working in synergy with other anti-folate drugs.(58,61) Other anti-folate drugs in common use include the urinary tract antibiotic, Bactrim (trimethoprim/sulfamethoxazole) the rheumatology drug, methotrexate, and the anti-seizure drug Dilantin (phentoin). Maternal exposure to anti-folate drugs such as methotrexate Bactrim and Dilantin increase risk of neural tube defects in the fetus up to six-fold. (85-87) Maternal folate supplementation has been shown to reduce incidence of fetal neural tube defects (NTD), and folic acid fortification in food supply was mandated in 1998. (85-87)(100-103) Glyphosate Inhibits the Shikimate Pathway Glyphosate’s known mode of action is inhibition of the shikimate pathway in plants, fungi, bacteria and parasites.(58) Glyphosate blocks the pathway which produces Folate, Ubiquinone (Co-Q10), Vitamin K, and the aromatic amino acids tryptophan, phenylalanine, and tyrosine. Government Regulators Deemed Glyphosate Safe for Humans Government regulators deemed glyphosate safe for us humans because we lack the shikimate pathway. They forgot to consider that we humans depend on the shikimate pathway in plants and gut bacteria for our folate (vitamin B9), to prevents neural tube defects. If your lunch salad comes from an agricultural field treated with glyphosate which blocks the plant’s ability to synthesize folate, how much folate are you getting in your meal ? If you are ingesting glyphosate in your food, blocking your gut bacteria from synthesing folate, how soon will you be rendered folate deficient? Dr Bekaert says in 2008, “Humans cannot synthesize folates (vitamin B9) and thus have to rely on plant food supplying these essential vitamins.“(104) Dr Craig Roberts suggests that Glyphosate may serve as anti-folate, anti-parasitic drug ,He says:(58) ” it is likely that the shikimate pathway is important for supply of folate precursors in this parasite….inhibitors of EPSP synthase (such as glyphosate) can act in synergy with conventional antifolates and may be a useful addition to the agents used against apicomplexan parasites.”(58) A quote from a University of Chicago Press Release 1998 (61) explains that Glyphosate blocks production of folate: “Effective new ways to inhibit parasites that cause malaria, toxoplasmosis and cryptosporidiosis” June 25, 1998.(61) “Dr. McLeod’s team showed that glyphosate, …could block the production of folate, inhibiting parasite growth and survival. Glyphosate proved effective against malaria strains that were resistant to an anti-malarial medicine, pyrimethamine, which interrupts folate processing at a different point. To confirm the finding, they demonstrated that these folate-starved parasites could be rescued, in the test tube, by giving them folate.”(61) Brazil Annual Pesticide Sales Surpasses the US Left Image courtesy of Reuters. Brazil sales of herbicide (glyphosate) exceeds that of US.(81) According to Paulo Prada in her 2015 article, Brazil has a huge appetite for pesticides and herbicides, surpassing annual sales in the US.(81) Poalo Prado explains that in Northeast Brazil, irrigation canals were built, transforming previously arid land into fertile farm land. These open air irrigation canals are heavily contaminated with herbicides and pesticides liberally applied to the crop fields. Life is primitive for the agricultural workers who live without piped in water for their dwellings. The local workers use the open air irrigation canals for their drinking water, thus are heavily exposed to herbicide and pesticide runoff. House Passes 1.1 Billion Zika Virus Bill. Methyl-Folate is Cheaper. Instead of spending 1.1 Billion dollars on a “controversial” Zika Virus Bill, I have a better idea for prevention of microcephaly and neural tube defects. (90) Suppose we instead allocate 100 million dollars to give out free methyl-folate tablets to all pregnant women exposed to glyphosate here in the US, and in Brazil. That would solve the problem at a fraction of the cost, saving a Billion Dollars.(90) 53 Countries Have Mandatory Flour Fortification with Folate Folate fortification of flour for prevention of neural tube defects (anencephaly, microcephaly, spina bifida etc.) is mandated in 53 countries. Fortification of flour with folic acid was mandated in the US in 1998, the most successful public health measure in history, with reduction of neural tube defects by 36%.(100-103) In 2009, Dr Oakley declared this success story a “modern miracle of epidemiology”.(103) Study Blood Folate Levels in North East Brazil Why not allocate research funds to study blood folate levels in women in Northeast Brazil at high risk for having babies with neural tube defects? This was done here in the US before and after starting folate fortification in 1998, showing reduction incidence of neural tube defects by 36%.(101) Folate deficiency (blood folate levels less than 3 ng/ml)) decreased from 21% to less than 1% of the population. (101) In Australia, mandatory fortification of bread with folate and iodine was introduced in 2009, resulting in a 50-80 per cent reduction in neural tube defects in at-risk indigenous women and teenagers.(100-112) Reducing Microcephaly in Brazil with Folate Fortification Studies done in Brazil shows folate deficiency is severe, affecting 94% among the poor.(113) Folate fortification of flour in three south American countries (Brazil, Argentina, Chile) resulted in significant reduction in 52 different fetal anomalies including reduction in microcephaly and anencephaly.(114) Currently all South American countries except Venezuala have mandatory folate fortification legislation.(115) In populations using folate fortification there have been decreases in neural tube defects from 30-50%.(115) How is Such an Error Possible ? You might ask the obvious question, “how is such an error in thinking possible” that the government would waste a billion dollars on Zika instead of Folate Fortification? This is called CrimeStop or “Protective Stupidity“, aptly described in 1984 by George Orwell (91): “The mind should develop a blind spot whenever a dangerous thought presented itself….Crimestop, they called it in Newspeak….the Party says the earth is flat’, ‘the party says that ice is heavier than water’—and trained himself in not seeing or not understanding the arguments that contradicted them.” “Crimestop means the faculty of stopping short, as though by instinct, at the threshold of any dangerous thought. It includes the power of not grasping analogies, of failing to perceive logical errors, of misunderstanding the simplest arguments…”…”Crimestop, in short, means protective stupidity.”(91) Using Fear and Smear Tactics to Distract Attention from Monsanto This article in the Huffington Post Feb 16 is typical of the Monsanto tactics to distract attention away from Roundup glyphosate as the cause of the birth defects in agricultural workers in Brazil; A Viral Story Links The Zika Crisis To Monsanto. Don’t Believe It. by Anna Almendrala Senior Healthy Living Editor Huffington Post. Anna’s piece is pure Monsanto propaganda masquerading as journalism, don’t believe a word of it. If you trust anything Monsanto says, then I have a bridge to sell you. Monsanto has known for decades that Glyphosate causes birth defects, see this report: Roundup and birth defects. Is the public being kept in the dark ? by Michael Antoniou Earth Open Source June 2011 Search Google Scholar for articles with key words “microcephaly pesticide“ : you will see 2160 articles pop up. Glyphosate is “Probably Carcinogenic to Humans” A number of studies show glyphosate exposure doubles the incidence of Non-Hodgkins Lymphoma.(92) As reported in Lancet Oncology by Dr Kathryn Guyton, on March, 2015, 17 experts from 11 countries met in Lyon France and classified glyphosate as “probably carcinogenic to humans” (89) Zika Distraction from Glyphosate – The Elephant in the Room Certainly, maternal viral illness with Rubella, (CMV) cytomegalovirus and Zika are all risk factors for fetal demise, and fetal malformations, and are best avoided.(93-95) However, the Zika Virus is a distraction from the real cause of the problem, massive glyphosate exposure to pregnant agricultural workers in Brazil. Glyphosate is a patented anti-folate drug, Anti-folate drugs are known to cause microcephaly and neural tube defects in animals and humans. Professor Don Huber, GMO Food and Glyphosate Increased incidence of birth defects in the population caused by exposure to the anti-folate agent, glyphosate is only the “tip of the iceberg”. The adverse health consequences of GMO food and glyphosate contamination of our food and water supply are much more extensive as outlined in a series of articles posted on the Stephanie Seneff home page. Here is a quote from Professor Don M. Huber:(88) from his document GMO Failed Promises Flawed Science Serious Health Safety Issue ” Future historians may well look back upon our time and write, not about how many pounds of pesticides we did or did not apply, but about how willing we are to sacrifice our children and jeopardize future generations for this massive experiment we call genetic engineering that is based on failed promises and flawed science, just to benefit the bottom line of a commercial enterprise.” Dr. Don M. Huber Link to this article: http://wp.me/p3gFbV-3En Jeffrey Dach MD 7450 Griffin Road Suite 190 Davie, Fl 33314 954-792-4663 Articles with related interest: Dont Ask for HIV Test Ask For Glyphosate Test Curing Autism with Antibiotics Berberine Antdote for an Epidemic References For references, please view original publication. https://greenmedinfo.com/blog/zika-virus-or-roundup-herbicide-cause-microcephaly

Growing evidence links Covid-19 injections with neurodegenerative disease This includes Alzheimer's and dementia - a moratorium on these genetic injections is long overdue. World Council for Health Written by World Council for Health steering committee member and Health & Science Lead Christof Plothe DO. Alzheimer's disease and dementia already affect every second human on our planet. It is a personal tragedy with gigantic socioeconomic implications. Many people around mod-RNA Covid-injected people have reported personality changes and a decline in cognitive functions in themselves and the people around them. More and more studies linking neurodegenerative diseases such as Alzheimer's with mod-RNA Covid-19 injections are being published as I write. grayscale photography of person covering face Photo by Danie Franco on Unsplash Usually, for a medication to be licensed, it must first be proven safe, as regards autoimmunity, cancer, and fertility. Strangely, this requirement has not been met for Covid-19 injections, and this year we are seeing an unusual rise in infertility, cancer, autoimmune diseases and now also a growing incidence of symptoms of cognitive decline. Note that this trend began in 2021 when the Covid-19 injections were first rolled out and not 2020, when Covid-19 was declared a pandemic. Share Spike proteins and the blood-brain barrier It is well known that spike proteins – produced as a result of mRNA Covid-19 injections – cross the blood-brain barrier, potentially damaging the brain. Several studies have examined this phenomenon and found evidence of spike protein accumulation in the brains of individuals who received Covid-19 shots. For example, a study conducted in May 2023 discovered spike protein presence in the brains of individuals affected by Covid-19 shots, even years after injection (Seneff, 2023). This long-term exposure to spike proteins was associated with neuronal damage. Another study from Spring 2022 (Mörz, 2022) reported the presence of spike protein in the brain of a deceased person who had received the Pfizer/Biontech injections. There is, therefore, no longer any reasonable doubt that spike proteins formed in human cells as a result of mod-RNA "vaccination" are able to enter the brain and cause damage there at will. Studies showing an increase in neurodegenerative diseases just keep coming A recent comprehensive study conducted in South Korea (Roh, 2024) further contributes to the discussion. The study randomly assigned half of the population of Seoul, aged 65 years or older, to receive Covid-19 shots and collected data on their well-being. The analysis, based on a large sample size of 558,017 individuals, revealed a significantly increased incidence of mild cognitive impairment (MCI) and Alzheimer's disease in those who received mRNA Covid-19 shots compared to the unvaccinated group. The study's findings indicate that individuals who received mRNA Covid-19 shots had a higher risk of developing mild cognitive impairment and Alzheimer's disease. This risk increased over time, suggesting the possibility of permanent and compounding damage, and was double the expected incidence after only three months. It thus increased the risk of mild cognitive impairment by 138% and the risk of Alzheimer's by 23%. Here are yet more studies indicating neurodegenerative decline after Covid-19 mod-RNA injections: A study published in Cureus in 2023 (Seneff, 2023) explored the potential role of the spike protein in neurodegenerative diseases and highlighted cumulative exposure to spike proteins as a risk factor. Another study published in the same year (Radomyslsky, 2023) investigated the association between Covid-19 injection and the development of Alzheimer's disease. The potential for the production of amyloidogenic protein (Valeria, 2022) – a protein associated with Alzheimer's – was demonstrated in 2022. Another paper published in 2023 shows the spontaneous formation of amyloid-like self-assembling nanostructures that might induce protein misfolding or even amyloidosis (Morozova, 2023). Ongoing monitoring and investigation into the long-term neurological impacts of these injections are urgently needed and represent another red line that should not be crossed in the experimental use of a novel gene therapy. Cognitive decline after Covid infection of "vaccinated" people People over 85 with Covid-19 were at significantly increased risk for a new diagnosis of Alzheimer's disease within 360 days after the initial Covid-19 diagnosis (Wang, 2022). The mechanism of this association has been the topic of numerous studies (Chen, 2022). Since several studies have demonstrated a so-called class switch of antibodies to ineffective IgG4 antibodies following “vaccination” (Irrgang, 2023; Kalkeri, 2024), people are left with a weakened defence against a new Covid-19 infection. Many reports describe a sudden and immediate worsening of Alzheimer's symptoms in the Covid-19 "vaccinated" after another acute infection. Often, this will be labeled Covid-19-induced, but instead, it seems to be the result of a weakened immune system incapable of clearing the viral infection as a result of Covid-19 injections. Conclusion: stop the injections, now In conclusion, evidence suggests an association between mRNA Covid-19 injections and the development of neurodegenerative diseases. Studies have shown the ability of spike proteins to cross the blood-brain barrier and cause damage to the brain. Additionally, comprehensive research from South Korea found an increased incidence of mild cognitive impairment and Alzheimer's disease in individuals who received mRNA Covid-19 shots. Given that 70% of the world's population has been injected with some form of Covid-19 gene therapy injections, an immediate moratorium should be implemented. If you find value in this Substack and have the means, please consider making a contribution to support the World Council for Health. Thank you. Donate Sources: Chen F, Chen Y, Wang Y, Ke Q, Cui L. The COVID-19 pandemic and Alzheimer's disease: mutual risks and mechanisms. Transl Neurodegener. 2022 Sep 11;11(1):40. doi: 10.1186/s40035-022-00316-y. PMID: 36089575; PMCID: PMC9464468. Irrgang P, Gerling J, Kocher K, Lapuente D, Steininger P, Habenicht K, Wytopil M, Beileke S, Schäfer S, Zhong J, Ssebyatika G, Krey T, Falcone V, Schülein C, Peter AS, Nganou-Makamdop K, Hengel H, Held J, Bogdan C, Überla K, Schober K, Winkler TH, Tenbusch M. Class switch toward noninflammatory, spike-specific IgG4 antibodies after repeated SARS-CoV-2 mRNA vaccination. Sci Immunol. 2023 Jan 27;8(79):eade2798. doi: 10.1126/sciimmunol.ade2798. Epub 2023 Jan 27. PMID: 36548397; PMCID: PMC9847566. Kalkeri R, Zhu M, Cloney-Clark S, Plested JS, Parekh A, Gorinson D, Cai R, Mahato S, Ramanathan P, Aurelia LC, Selva KJ, Marchese AM, Fries L, Chung AW, Dunkle LM. Altered IgG4 Antibody Response to Repeated mRNA versus Protein COVID Vaccines. medRxiv [Preprint]. 2024 Jan 18:2024.01.17.24301374. doi: 10.1101/2024.01.17.24301374. Update in: J Infect. 2024 Mar;88(3):106119. doi: 10.1016/j.jinf.2024.106119. PMID: 38293205; PMCID: PMC10827267. Morozova, Olga V. and Manuvera, Valentin A. and Barinov, Nikolay A. and Subcheva, Elena N. and Laktyushkin, Victor S. and Ivanov, Dimitri A. and Lazarev, Vassili N. and Klinov, Dmitry V., Self-Assembling Amyloid-Like Nanostructures from SARS-CoV-2 S1, S2, RBD and N Recombinant Proteins. Available at SSRN: https://ssrn.com/abstract=4592840 or http://dx.doi.org/10.2139/ssrn.4592840 Radomyslsky Z, Kivity S, Lidar S, Bentur N, Korn L, Nissanholtz-Gannot R, Sternberg S, Halevi Hochwald I, Reges O, Alon Y, Saban M. Association between COVID-19 vaccination and critical outcomes among older adults with dementia: a comparative cohort study. Front Public Health. 2023 Oct 2;11:1281266. doi: 10.3389/fpubh.2023.1281266. PMID: 37849724; PMCID: PMC10578450. Seneff S, Kyriakopoulos AM, Nigh G, McCullough PA. A Potential Role of the Spike Protein in Neurodegenerative Diseases: A Narrative Review. Cureus. 2023 Feb 11;15(2):e34872. doi: 10.7759/cureus.34872. PMID: 36788995; PMCID: PMC9922164. Valeria Castelletto & Ian W. Hamley. Amyloid and Hydrogel Formation of a Peptide Sequence from a Coronavirus Spike Protein. CS Nano 2022, 16, 2, 1857–1867. Publication Date:January 4, 2022. https://doi.org/10.1021/acsnano.1c10658 Wang L, Davis PB, Volkow ND, Berger NA, Kaelber DC, Xu R. Association of COVID-19 with New-Onset Alzheimer's Disease. J Alzheimers Dis. 2022;89(2):411-414. doi: 10.3233/JAD-220717. PMID: 35912749; PMCID: PMC10361652. https://substack.com/home/post/p-146712069

Why Sherpas & Billionaires Don't Get Jet Lag Can Fix Chronic Disease Synchronizing biological clocks, GIGO vs QIQO, implications for modern environmental mismatches and healing chronic disease. Dr. Syed Haider There is no sleep as delicious as jet-lagged sleep. But it’s also inconvenient, especially if you need to get back to work, or make the most of precious vacation time. Like many living in modern industrialized societies today I have a lot of experience with globe trotting jet lag. I always get constipated for a few days (not the first thing you think of with jet lag, but it happens), and of course suffer through the usual daytime fatigue lulling me to sleep in the afternoon only to wake up again at 2 - 4am. Jet lag can also cause a lot of other symptoms in susceptible people: Digestive upset including the aforementioned constipation, but also nausea, bloating, and changes in appetite Headaches, trouble concentrating, impaired judgment and decision making, memory lapses. Irritability, apathy, anxiety, and depression. Recovery times vary person to person, but can take as long as a day for each time zone crossed, especially if you don’t make much effort to resist the enticing daytime sleep. The advice I’ve gotten over the years to minimize jet lag from hard charging, Type-A acquaintances who can’t suffer the downtime: once travel begins, eat on the destination schedule (so decline all the weirdly timed airline food) spend a couple hours in the noon-time sun for a couple days on arrival get grounded at the destination take melatonin Thank you for reading Dr. Syed Haider. This post is public so feel free to share it. Share Numbers 1 and 2 help to get your body on the correct circadian rhythm, though I’ve since learned early morning sun is even more important than afternoon sun for this purpose. Grounding is a source of free electrons that are required to run your body's DC bio-electrical currents, and they also have powerful antioxidant effects. Free electrons can bypass inflammatory tissue barriers that can keep out chemical antioxidants. Melatonin is thought of as the sleep hormone, though it has many other effects on our biology including immune regulation, direct and indirect antioxidant effects, hormonal regulation, blood pressure lowering, and anti-cancer properties. The melatonin released by the pineal gland at night puts us to sleep, but 95% of the melatonin in our bodies resides within our mitochondria which are the energy powerhouses within every cell. Melatonin is only released by the pineal gland in response to darkness. It’s commonly used by shift workers, and globetrotters alike to re-set their circadian rhythms quickly. There are documented side effects of melatonin use including headaches, nausea, dizziness and agitation, which suggest that it may not be as benign as many people make it out to be. Generally speaking it’s best not to try to hack biology by exogenous administration of endogenously created substances: if you make it, don’t take it, because there may be unpredictable butterfly effects that are impossible to trace back. An apt metaphor for this kind of biohacking is attempting to code a computer in the base machine language of 1s and 0s which is basically impossible for humans to understand. Where the metaphor breaks down is that at least we know how to perfectly map human interpretable languages to machine language (using compilers), but we don’t know all the rules of our own biochemistry, there are missing pieces and the interrelationships in living systems are too unpredictable and complex to model in each patient. It is probable impossible to ever sort it out because humans are not simple automatons. Everything we think, feel and believe affects our biology and biochemistry. How can you model all of that without a direct interface into a person’s mind and heart? Organization of Computer Systems: ISA, Machine Language, Number Systems All of melatonin’s effects sound great in theory, but you can have too much of a good thing, especially when that thing is part of an intricate network of feedback loops, where exogenous administration artificially affects many other things that suddenly react to greater than expected melatonin levels at the “wrong” time according to the body’s own biological clocks. Exogenous melatonin can lower cortisol (pro-inflammatory), suppress fertility, raise growth hormone, cause relative insulin resistance and relative hypothyroid effects. Melatonin is the body’s strongest antioxidant, but we know that antioxidants in excess can exhibit pro-oxidant effects. This might be helpful for cancer since that can kill cancer cells, but it might be harmful as well to regular cells and their mitochondria. Excess melatonin will also disrupt serotonin metabolism because Serotonin is the precursor used to make melatonin. If the body gets melatonin from outside then there will be excess serotonin, which wasn’t needed to make melatonin. This is why melatonin is relatively contraindicated in those taking SSRIs (selective serotonin reuptake inhibitors) which also increase serotonin levels. Elevated levels of serotonin can cause insomnia, anxiety, irritability and gut upset among other things, perhaps helping explain why chronic melatonin use so often doesn’t help patients with refractory insomnia (more on chronic effects of melatonin use towards the end). Even short term some of these might help explain negative side effects experienced by some when taking melatonin, and there might be mid term effects that aren’t connected back to the melatonin administration - hypothetically speaking, if you come down with something 2 weeks after taking melatonin how likely are you to make the connection? I acknowledge that many people will use melatonin anyway (I used it too in the past), it just goes against my c current understanding of the principles of health. But no worries, theres much more interesting stuff below: what private jets can teach us about jet lag and how to prevent it! Not All Jets Lag A little known and almost universally inaccessible approach to preventing jet lag is worth examining anyway because of what it might teach us about jet lag and what we can do about it (an ounce of prevention is worth a pound of cure). I learned from a famous private jet salesman on Youtube (to be clear I wasn’t in the market for a private jet) that flying at lower altitudes with better cabin pressure prevents jet lag because oxygen tension remains higher throughout the flight - if this personal observation is true, it would explain why super-billionaires don’t all fly in Airbus size jumbo jets, but tend to prefer the Gulfstream, which has the highest cabin pressure of any private jet. The Gulfstream G600 can maintain an effective cabin “altitude” of 3,800 feet even at a cruising altitude of 45,000 feet. Steve Varsano : The Jet Business - Ultimate Jet | The Voice of Business Aviation since 2008 Jet salesman Steve Varsano’s jet-interior-shaped office space On the other hand commercial airlines usually maintain a cabin pressure equivalent to an altitude of 6,000 to 8,000 feet. So flying in a Gulfstream is easier than staying in Denver Colorado (elevation 5000 ft), while flying commercial is the equivalent of rapidly ascending a tall mountain within a matter of minutes, a feat that can lead to high altitude sickness (HAS) in 25% of those who sleep above 8000 feet, and can cause symptoms in more sensitive people at much lower elevations. So maybe jet lag is a subset of mild high altitude sickness (i.e. oxygen/energy deprivation) that makes it harder to adjust to a new time zone. That would suggest that treatments for high altitude sickness, or mimicking the physiological changes that occur when someone acclimates to higher altitudes over time might help with jet lag (and be much more accessible than flying private). Acclimatization to high altitudes involves several physiological changes that help the body cope with lower oxygen levels. Key mechanisms include: Increased Ventilation: Breathing rate and depth increase to intake more oxygen. Red Blood Cell Production: The body produces more red blood cells to enhance oxygen transport. Hemoglobin Affinity: Hemoglobin’s affinity for oxygen adjusts to release oxygen more efficiently to tissues. Capillary Density: Capillaries may increase in number, improving oxygen delivery to tissues. Mitochondrial Efficiency: Cellular adaptations enhance energy production efficiency under low oxygen conditions. Thank you for reading Dr. Syed Haider. This post is public so feel free to share it. Share The top of the list of treatments for high altitude sickness is obviously just to go back down to a lower altitude and/or get more oxygen (mimicking number 1 - 4 above). Equally obviously in an airplane you’re not going to be able to go back down for the duration, but you could super-oxygenate yourself using a portable oxygen concentrator (available via prescription. details on flying with one here). It’s not safe to use 100% oxygen for prolonged periods, but you could titrate the device to deliver just enough oxygen to counteract the effects of the lower oxygen tension on flights that cruise at effective altitudes of 6-8000 feet. Traveling with a Portable Oxygen Concentrator (Tips) | 2024 Running the calculations on a typical flight with cabin pressure set to the equivalent of 6000 feet above sea level we find that you only need about half a liter per minute from the oxygen concentrator in the average person to raise inspired oxygen concentration enough to counteract the effects of altitude and give you the same amount of oxygen delivery you would expect at sea level. A more convenient and cheaper alternative to lugging around a portable oxygen concentrator is prescription acetazolamide (diamox) carried by many hikers who’ve had experience with altitude sickness before. Acetazolamide works primarily by removing bicarbonate (baking soda is sodium bicarbonate) from your bloodstream into your urine and therefore causing metabolic acidosis in your body, which stimulates your brain to increase your breathing rate, which then increases your blood oxygen levels. There is another little known possibility for the treatment and prevention of acute mountain sickness which is the simple, cheap and readily available chemical ammonium chloride. Its chemical decomposition in the bloodstream leads to the creation of hydrogen ions and CO2. Hydrogen ions bind and neutralize bicarb lower the pH by a different avenue than diamox, but having the same effect to stimulate respiration. Increased CO2 levels will also stimulate increased respiration. So both would tend to raise oxygen levels as a result. Apparently useful for a number of indications including kidney stones, digestive trouble, preventing metabolic diseases and to give goats a beautiful sheen on their coat for shows. There was one small study published in 1937 where a dozen volunteers took 5 grams of ammonium chloride three times a day with meals (much higher than normal dosing ranges for its one remaining medical indication, severe metabolic alkalosis) while ascending to altitude. Unfortunately the results were weirdly completely the opposite of what you might expect, which raises the possibility that pharmaceutical industry bias creot in as it usually does when any simple non-prescription therapy threatens the status quo. That paper also referenced a few other preliminary research findings that had seemed promising at 1/10th the dose. Given the mechanisms at play it would be interesting if someone revisited this research. Traditional herbal remedies for high altitude sickness might be helpful as well, and I suspect gentler and safer than acetazolamide (though none that we know of work exactly the same way it does): Sea Buckthorn ("Shan-Ji" in TCM) Mechanism: Sea buckthorn is rich in antioxidants, vitamins (especially vitamin C), and fatty acids, which can enhance oxygen utilization and reduce oxidative stress at high altitudes. Studies: Research has shown that sea buckthorn can improve high-altitude polycythemia (an increase in red blood cells due to low oxygen levels), which helps in better oxygen transport and utilization in the body. Rhodiola algida ("Hong Jing Tian" in TCM) Mechanism: Rhodiola algida contains active compounds like salidroside and rosavin, which are known to enhance physical performance, reduce fatigue, and increase resistance to stress. These properties can be beneficial in preventing AMS by improving the body's ability to cope with hypoxia (low oxygen levels). Studies: It is traditionally used by Tibetan people to prevent AMS. Experimental studies suggest that Rhodiola spp. can improve acclimatization and reduce symptoms of AMS by enhancing oxygen efficiency and reducing oxidative stress. Zuo-Mu-A decoction (no English name found) Mechanism: This traditional Tibetan medicine contains various herbs that are believed to work synergistically to enhance acclimatization to high altitudes. The exact mechanism is not fully understood, but it is thought to improve blood oxygenation and reduce oxidative stress. Studies: Experimental studies in rats have demonstrated its efficacy in preventing high-altitude polycythemia, indicating a potential benefit in improving oxygen delivery and reducing AMS symptoms. Ginkgo (Ginkgo biloba) Mechanism: Ginkgo biloba is known for its vasodilatory properties, which can improve blood flow and oxygen delivery to tissues. It also has strong antioxidant effects, which can protect cells from oxidative damage caused by hypoxia. Studies: Clinical studies have shown that Ginkgo biloba can reduce symptoms of AMS, such as headache and dizziness, by improving microcirculation and reducing oxidative stress. Roseroot (Rhodiola rosea) Rhodiola: Mental Health Benefits, Side Effects, and More If there are no side effects it’s probably not medicinal Mechanism: Similar to Rhodiola algida, Rhodiola rosea contains adaptogenic compounds like rosavin and salidroside, which help the body adapt to stress and improve physical performance. It also has antioxidant properties that protect against hypoxia-induced damage. Studies: Studies have demonstrated that Rhodiola rosea can enhance endurance, reduce fatigue, and improve the body's resistance to hypoxia, making it effective in preventing and reducing symptoms of AMS. Coca (Erythroxylum coca) Mechanism: Coca leaves contain alkaloids such as cocaine (so good luck sourcing these, only included here in the interests of being comprehensive, although millions in the Andes regular chew them without adverse effects), which can stimulate the central nervous system, increase oxygen intake, and improve overall physical performance. These effects can help counteract the symptoms of AMS. Studies: Indigenous populations in the Andes have used coca leaves for centuries to prevent and treat AMS. Scientific studies support its effectiveness in reducing symptoms of AMS, such as headache, nausea, and fatigue, by enhancing oxygen utilization and reducing oxidative stress. These herbs work through a combination of improving oxygen delivery, enhancing physical performance, reducing oxidative stress, and promoting acclimatization to high altitudes, thereby helping to prevent and mitigate the symptoms of acute mountain sickness. Along the same lines methylene blue (may need to avoid with SSRIs, severe kidney disease, G6PD deficiency) may attenuate jet lag and is used by biohackers and Long COVID/Vax injury sufferers nowadays because it increases mitochondrial oxygen production (other of the natural acclimatizing adjustments the body eventually makes to prolonged stays at altitude) without the addition of more oxygen. Basically it improves your ability to create energy and that’s really what we need oxygen for in the first place. Thank you for reading Dr. Syed Haider. This post is public so feel free to share it. Share There are other ways to improve mitochondrial energy production, most importantly for this purpose via plenty of direct sunlight before the flight. One way this works is that the key to mitochondrial energy production is proton tunneling, which is required for functioning of the ATPase enzyme in the inner mitochondrial membrane that produces ATP, the chemical energy currency of cells. Proton tunneling is a quantum effect that depends on the existence of coherent quantum domains in water as well as 4th phase structured water. Coherent domains are masses of water molecules vibrating at the same frequency, and structured water is a gel like water that forms next to liphophilic (water loving) surfaces in cells and leads to charge separation with one area of water having a negative charge next to the surface and another area having a positive charge. Both of these effects in water are increased by exposure to natural sunlight and the earth’s natural electromagnetic fields, e.g. the Schumann resonances - both of which are missing in flight. So another cause of jet lag on the flight is likely missing sun and natural EMFs, while being exposed instead to blue spectrum light and non-native electromagnetic fields instead (as well as increased exposure to cosmic radiation?). It’s usually impossible to get into natural sunlight for the duration of your trip, unless you have longer layovers (sunlight that filters through clear window glass is deficient in balancing UV-A, UV-B and infrared wavelengths that help to counteract the stressful nature of visible blue light). The best way to mitigate this may be to have a good tan (melanin in the skin can absorb any wavelength of radiation) and plenty of exposure to sun and natural outdoor electromagnetic fields in the days and weeks leading up to the flight, and after arrival, so as to have a strong reserve of coherent, structured biological water (some people also advocate structuring your drinking water by exposing it to light and spinning it in a vortex prior to consumption) and then replenish it after the flight. There is also an herbal cream we’ve found to be helpful for mitigating the effects of EMF on children and others who are particularly sensitive to it that could be used in this situation. EMF Mitigating Cream: 10 parts Castor oil 6 parts Hemp seed oil 1 part bee propolis 1 part neem oil 1 part rosemary extract 1 part coriander extract I was personally surprised to discover that there was data on EMF protective effects of Rosemary (eg here and here) and bee propolis (eg here). There are energetic reasons to include the other ingredients, but I’m not aware of studies having been done on them. If anyone has EMF sensitivity they should try this cream all over the body and report back any effects. It’s also important to note that many people with chronic diseaes (and jet lag) likely have EMF sensitivity they just aren’t aware of it. See Robert O Becker’s books and The Invisible Rainbow if you remain unconvinced of the thoroughly documented negative biological effects of most man-made non-ionizing radiation. Finally dehydration (airplane air is very dry), alcohol, caffeine, stress and advanced age can all play a role in triggering and prolonging jet lag, though older age is probably mostly a marker for more time spent living sub-optimaly, destroying organ reserve and resilience (both of which can be reversed). Usually when I take a long flight east my schedule will lag the final time zone I end up in by a few hours. So it’s not like my body thinks its all the way back home, it seems to think its a few time zones over. For example I’ll usually get tired in the afternoon say 3-4 pm and crash, and then wake up at 1-3 am unable to sleep any more. In terms of my origin time zone that translates to falling asleep at 8am and waking at 6pm (to be clear I don’t sleep all day at home, but have a normal schedule). So it would seem that my body thinks I’m a few time zones West of where I actually am. On my last 9-time-zone trip halfway around the globe I lost a lot of sleep for a couple days during the flights since I find it hard to sleep sitting up, but had great success preventing significant jet lag on arrival with a few simple interventions. I only ate during daytime wherever I was in my travels, and once I arrived I made sure to eat a good breakfast early every morning and didn’t consume anything at the destination after sunset - including food, information, light (i.e. no room lights or screens). I wore a pair of wraparound blue blocker sunglasses throughout the trip to block excess blue light (the darker the better, since light intensity is also important, especially at night). I made sure to get morning and afternoon sun both for 1-2 hours each at the destination. I arrived at my destination at 2am and the first day got my morning sun and then fell asleep for a couple hours until the afternoon, then got some more sun, and then slept normally that night until the next morning, which was a first for me after such a long trip and really surprising. The next day I got morning sun, afternoon sun and then took a nap again for a couple hours in the afternoon and again slept normally through the night. I was constipated on the flight, but it was less severe than usual, resolving within 24 hours once I landed. So basically I had some sleep to catch up on since I slept very poorly on the planes and missed a lot of sleep during the prolonged travel (there were two long layovers), but other than that I had very minimal jet lag without nighttime insomnia or excessive daytime fatigue the first couple days. After that I found that I could sleep longer in the afternoon if I let myself, but it wasn’t the usual overpowering, siren-song type of jet lag sleep I’m accustomed to. It was optional. Maybe next time I’ll try changing it up some more with some herbs and/or the EMF skin cream. Recent research by Huang et al also confirms that the best cure for jet lag is a big breakfast in the early morning at the destination and plenty of morning sunlight. These two signals help to synchronize central and distal body clocks to the new time zone and eliminate jet lag fast. They are also probably the two most important signals to help cure a normal case of insomnia. By the way, many people who are trying to fix chronic illness nowadays will try intermittent fasting, and it’s easiest to implement that by skipping breakfast, but this is the worst way to do it because it sends your body the wrong signals. LATELIFE MUSINGS...: EAT LIKE A KING The old wisdom that taught us to breakfast breakfast like a King and dinner like a pauper is correct, but I would go further and say skip dinner (perhaps that’s what the saying actually means anyway). Most people throughout human history counted themselves lucky to eat twice a day, let alone thrice. You often hear that breakfast was invented by cereal companies, but it was just coopted by them. A healthy breakfast for most people probably looks more like steak and eggs (and some healthy carbs) than an all-out refined sugar bomb and sets you up calorically and hormonally for an active day. Steak and Eggs Skillet with Chimichurri and Sweet Potatoes The Inputs Dictate the Output, i.e. Garbage In Garbage Out, illustrated via Light, Quantum Coherence, Structured Water, Cold, Seasonal Variations, Deuterium, etc Garbage in garbage out refers to the computer science truism that poor quality input, for example when trying to model the likelihood of some outcome, will produce poor quality output, i.e. you’ll probably get the answer wrong. The alternative is Quality in Quality Out or QIQO. The same aphorism applies to jet lag. If you provide the right inputs at the right times you won’t have jet lag. Jet lag is really a function of decreased resilience due to suboptimal environmental inputs. This is the essential truth about all chronic disease that we ignore to our own detriment because it’s easy to just go with the flow. Unfortunately that flow is like a riptide that will carry you out to sea and to your early demise unless you act fast and swim out of it, parallel to the shore. The good news is that once you make the effort and build new habits, they stick with you and it’s a lot easier to continue. So the basic prevention and cure for jet lag and insomnia is the same basic prevention and cure for any chronic health dysfunction in the modern world, because our dysfunctions are fundamentally caused by living out of sync with our environments, both external and internal (e.g. physiologically harmful thoughts, beliefs, emotions). Our external environments are tailor made for us, or we’re tailor made for them, depending on your perspective and Nature never makes mistakes, though we often misinterpret her perfection. On the other hand you could take the lesson that supplemental oxygen cures jet lag and extend that to chronic disease. Supplemental oxygen may also help allay the symptoms of chronic diseases, and be even more effective when taken inside a hyperbaric oxygen chamber. Both in or out of the chamber it works the same way by increasing stem cell production. But the easy way out will always come back to bite you in the end. There isn’t really an easy way. It’s an illusion. You can use various means to take the edge off, but ultimately you have to address root causes, because if you don’t the underlying problem will only worsen and eventually overcome the simple fix you found. The easy way is a temporary bandaid. Whereas going down a mountain to an altitude you’re more accustomed to makes sense physiologically speaking, using a hyperbaric chamber is the equivalent of going underwater where the partial pressure of oxygen is much higher. Even if you plan to live in a submarine it’s certainly not a natural signal to give your body. We aren’t designed for such high pressures. Health is a function of irreducibly complex inputs - i.e. you can’t mimic the sun by taking vitamin D, or even with a sunlamp. Understanding more about the ways this works for external inputs will help us respect Nature and submit to her dictates. In order to do that we’ll consider some fascinating, but little known facts about human biology and the central roles that light and water play in it. We already discussed the effect of light on quantum coherence and structuring of water and how that improves the energy production of mitochondria. EZ Water: The Fourth Phase Of Water (Part 3) - Live Vitae Structured water due to it’s thicker gel like consistency excludes particulate matter and cells, thereby protecting the walls of the blood vessels from damage and inflammation. The structuring of water is also the reason blood flows, and blood is what delivers oxygen and nutrients. When you have a hydrophilic (water attracting, not repelling) tube, like an artery or vein and you place it in a bucket of water, the water structures itself by charge separating as described above and starts flowing through the tube spontaneously, and so does blood, which is primarily made up of water. Blood circulation in an embryo begins even before the heart forms and starts pumping, i.e. it is not the pumping that moves blood, rather the heart acts more like a conductor, synchronizing the organs of the body (more on this in an upcoming post on the heart). Now, both quantum coherent domains and structured water form more easily in cold temperatures, which means you need less light energy to produce them. This means that near the equator where it’s warm all year round you need more light energy absorbed by your body water, and conveniently there is more light available during the year with 12 hour days throughout. Whereas up north you need less light in the winters when it is cold and the days are much shorter. In both of these situations our physiology if it is in sync with the natural environment will get just what it needs. Seasonal variations in light also affect weight gain because when temperatures are warmer and days are longer and food is plentiful, the body gets the message that it’s time to store up fat for the coming winter (remember blue light triggers cortisol, appetite, hyperglycemia and elevated insulin). When winter comes the days are short and food is naturally scarcer, and in the cold our bodies are stimulated to produce more heat, and use stored energy to do so. The Endless Summer (Remastered) - Official Trailer If you want an endless summer, head south. However nowadays winter never comes in industrialized societies, even up north, at least the signals that indicate it’s winter never arrive: we don’t change what we eat in the winter, because we don’t eat seasonally, and we don’t change our light environment either, because we spend all day and night indoors in temperature controlled environments with the lights on until all hours - our circadian biology gets the message that it’s always summer, the days are always long, the food always plentiful (you can eat more because you keep the lights on so long) and it’s never too cold. Our mitochondria naturally deplete water of deuterium, which is a heavy isotope of hydrogen. Water in the south has higher deuterium content while water up north is already deuterium depleted so our mitochondria may work more efficiently when exposed to it, with less need of the red and NIR spectrums to help boost their functioning, if we are living within a natural environment and drinking the local water up north (while being exposed to the natural temperature variations and seasonal foodstuffs). Not much is known about bioenergetics, since there is insufficient funding, but it has been shown that a weak DC electrical current flows in the Qi energy pathways mapped out by the Ancient Chinese 1000s of years ago (it was shown that grounding primarily enters free electrons into the meridians of the Spleen, Stomach, Liver, Gall Bladder, Kidneys, and Urinary Bladder). The energy flows because we are made up of biological semiconductors. Semiconductors hold electrons, and when they are excited by enough outside energy those electrons start to flow as electricity. Our biological semiconductors like collagen need to be charged with electrons from food and grounding (more grounding means you need less food), and “turned on” by incident light energy from the sun. Just like mitochondria they work better in the cold, and so need less energy from sunlight in northern winters, when there is naturally less sun available. https://robertobecker.net/research/bone-bioelectricity/ The concentrated blue light we’re exposed to is meant to be stimulatory - it’s the component of natural sunlight that triggers wakefulness, and stimulates the sympathetic nervous system to release catecholamines like dopamine and norepinephrine, which raise alertness, focus, motivation, BP and HR (which is why blue light dominant computer and smartphone screens are addictive by their very nature, in addition to the addictive nature of much of the software - but even if you need to use the apps, at least you can turn your screens red like I do and you may notice less of a pull to overuse them, and anyway your eyes and brain will benefit from it). Since blue light triggers dopamine, blue light dominant computer and smartphone screens are addictive by their very nature, in addition to the addictiveness programmed into the software - but even if you need to use the apps, at least you can turn your screens red like I do and you may notice less of a pull to overuse them, and either way your eyes and brain will benefit from it, since blue light without balancing infrared and UV-A kills retinal cells. The other wavelengths of natural sunlight have a balancing effect physiologically: UV-A stimulates nitric oxide which helps relax us and elevate our mood by increasing the levels of beta endorphins, as well as lowering blood pressure. It also affects hormonal and neurotransmitter levels. Red and near infrared wavelengths have healing and anti-inflammatory effects commonly leveraged by photo-biomodulation devices. Blue light is known to be toxic to cells in the eye, but the UV-A, red and NIR wavelengths protect against that by stimulating nitric oxide production, increasing antioxidants, suppressing inflammation and increasing mitochondrial energy production and mitochondrial numbers. Excess blue light, unmitigated by the other balancing wavelengths, raises cortisol levels, which lead to elevated blood sugar and insulin. When this becomes chronic it leads to decreased production of serotonin and melatonin, insulin resistance and leptin resistance (leptin is a natural appetite suppressant). The other wavelengths in light help to reduce stress, cortisol, blood sugar and insulin levels. Full Spectrum Light Bulb | SAD Lamp for Depression | BlockBlueLight However the answer is not to simply outfit all our homes with full spectrum bulbs, or even fancy red lights at night like they hang on the roads near certain beaches to prevent circadian disruption in spawning turtles. The photoperiod, i.e. the length of the day is also important (if you really can’t avoid night time lights then dim red bulbs are the least suppressive of melatonin production, try to keep the lux between 50-100 for the best effects). We need to balance light with dark every day and throughout the year depending on where we are on the earth. The natural spectrum of sunlight changes throughout the day. UV-A, red and NIR are most prevalent in the early morning and late afternoon, while UV-B, which stimulates vitamin D production is most prevalent in midday. comparing natural light and artificial light - Sunlight Inside UV-B is important for stimulating vitamin D production which can increase insulin secretion, inhibit the renin-angiotensin system of the kidney to help lower blood pressure, influence the production of sex hormones estrogen and testosterone, modulate the immune system, and directly affects the expression of over 900 genes. UV-B can damage skin, but the effect is mitigated by preconditioning your skin with the protective wavelengths in morning sunlight, and further decreased by getting healing late afternoon sun. These daily variations in light characteristics highlight the importance of getting regular sun exposure throughout the day, whether direct or indirect from reflected light even while in the shade outdoors. Knock-on Effects Serotonin production is stimulated by UV-A light in the morning, and as mentioned above, it is the precursor to melatonin, production of which is stimulated by darkness. If we don’t get enough light we don’t make enough serotonin, which means we won’t make as much melatonin later on even if we don’t turn on the lights. And simply taking melatonin on a chronic basis to fix the sleep problem will lead to other problems as mentioned briefly earlier, most obviously too much serotonin (also seen with SSRI use) since it’s no longer being converted to melatonin. Acute symptoms of higher serotonin include restlessness, agitation, confusion, hallucinations, tachycardia and arrhythmias, high blood pressure. tremors, nausea, vomiting, diarrhea. Chronically elevated serotonin will lead to increased cortisol production, prolactin excess, and altered levels of thyroid hormone, growth hormone, sex hormones, oxytocin, and insulin. Let’s trace out the further implications of just the first of those effects of higher serotonin: chronically elevated cortisol will lead to weight gain, insulin resistance, hypertension, heart disease, low immune function, muscle weakness, osteoporosis, mood disorders, cognitive impairment, reproductive hormone imbalances, skin and hair problems, and digestive upset. It does this by affecting the levels of insulin, thyroid hormones, sex hormones, growth hormone, prolactin, adrenaline, leptin and ghrelin. And we could keep going down each of these pathways documenting how each disruption spreads outward in every widening concentric circles over time from any unnatural tweak that is made to our physiology. This is why we can only effectively speak to our bodies using the natural signals they’ve been designed to understand. Health is a function of an irreducibly complex system of environmental inputs. You can never put an irreducibly complex environment in a simple pill. Hormonal Rhythms All our hormones are also on circadian rhythms. So if you get too much light throughout the year (by turning the lights on at sunset) you’re going to burn out your thyroid, adrenals, ovaries/testes, and everything else that is stimulated by light. Just like overeating refined carbs may help precipitate pancreatic exhaustion and diabetes, consuming too much light and the wrong kind of light (especially blue without the rest) will necessarily lead to exhaustion of all the hormonal systems that help you function during the day light hours (and disrupt nighttime-peaking hormones like melatonin, growth hormone, prolactin, and leptin). This will lead to the typical diseases we see all the time in the modern world: insulin resistance and diabetes (via stress, cortisol and glucose), cancer (via the last), hypothyroidism, heart disease (via stress and sympathetic overactivity), “adrenal fatigue,” chronic fatigue syndrome, burnout, autoimmune diseases (disrupted POMC), hypertension, etc. Thank you for reading Dr. Syed Haider. This post is public so feel free to share it. Share Conclusion So if you’re struggling with jet lag or insomnia, try eating early and getting your morning sun (and if its a bad case then consider some of the other things above) and let me know what happens. And if you’re struggling with chronic disease, try aligning yourself with your natural environment in order to optimize your hormonal cycles and other bodily functions that are designed for the natural environment. Finally to close the loop on the title re: Sherpas. Why don’t they get jet lag? Because they only fly up and down Mt Everest. Ha ha. Seriously though, there is no research I could find on jet lag differentials by population or background, but it would make sense that if jet lag is in part due to a form of high altitude sickness and is more likely in those living out of sync with their natural environments, then a Sherpa would be less prone to it since they are acclimated to high altitudes and live in touch with their natural surroundings. Let me know in the comments what you think! https://blog.mygotodoc.com/p/knowing-why-sherpas-and-billionaires

WARNING! Your Detox System Is UNDER ATTACK: The War On Our Heroes of Detox: P-Glycoprotein (Pgp) and CYP3A4 These Unsung Heroes of Detox Protect Your Body, Unless Someone Tricks You Into Shutting Them Off Tim Truth The body's ability to detoxify and defend itself against harmful substances is truly amazing. This article details two of the most amazing biological phenomenon related to detoxification I found while researching depopulation via mass poisoning operations. It revealed to me more than just a huge blindspot in the advice of the many quacks who never mention side effects or drug interactions, but also what appears to be a purposeful attack on our bodies’ key detox pathways for the purpose of increasing the toxicity of other poisons. In other words, drugs that shut down detox pathways are being pushed at large, and then other poisons that exploit the inhibited detox abilities are promoted that when combined complete the binary weapon. Among the vital molecules and enzymes involved in the amazing human body detox process, two proteins stand out for their key roles: P-glycoprotein (Pgp) and Cytochrome P450 3A4 (CYP3A4). These proteins are indispensable in protecting the human body from harmful toxins and poisons. They are both endogenous which means that they are naturally produced by our bodies (so there’s no money for supplement hawks to be made here) Our bodies continuously navigate a flood of incoming substances, many of which are toxins that could potentially disrupt or harm our systems. Pgp and CYP3A4 are crucial in protecting the body from such harmful compounds. P-glycoprotein (Pgp): The Cellular Bouncer P-glycoprotein, also known as multidrug resistance protein 1 (MDR1), functions like your own personal cellular bouncers - kicking out any troublemakers from your cells. Pgp is found in the cell membranes of various important tissues, including the liver, kidneys, intestines, and brain. Pgp actively pumps a wide range of substances out of cells which is absolutely vital for preventing the accumulation of toxic compounds within cells and our sanctuary organs like the brain. One of Pgp's most crucial roles is in the blood-brain barrier, where it prevents potentially harmful chemicals from entering the brain. By doing so, Pgp protects the central nervous system from toxins and drugs that could hamper neural function or cause catastrophic damage. Additionally, Pgp plays a significant role in drug metabolism and excretion, impacting the pharmacokinetics of many drugs and toxins. Pgp also protects other sanctuary sites in the body, such as the testes and placenta barriers, ensuring these critical areas remain free from harmful substances. Moreover, Pgp's action in the brain capillaries is a key mechanism for ridding the brain of toxins, keeping the central nervous system safe and functional. P-Glycoprotein Substrates and Inhibitors Pgp substrates are the substances that Pgp targets and pumps out of cells. Pgp substrates include a variety of drugs and toxins. Some notable examples include: ivermectin, mRNA vaccines (PEG is a substrate of Pgp), morphine, midazolam, remdesivir, HCQ … and there are many others. Pgp substrates are the drugs and toxins that accumulate in cells when Pgp is inhibited or genetically deficient. Pgp inhibitors, on the other hand, are substances that block the action of Pgp. When Pgp is inhibited, its ability to pump toxins and drugs out of cells and tissues is reduced, leading to increased levels of these substances within cells, potentially leading to terrible toxicity. Some notable examples of Pgp inhibitors include quercetin, CBD, THC, curcumin, green tea, milk thistle (silymarin), mistletoe, natto K2, ivermectin, curcumin (in turmeric), resveratrol (in grapes, wine, peanuts, blueberries and cranberries), grapefruit juice, caffeine, piperine (in black pepper), capsaicin (hot peppers), remdesivir, tannic acid, gingerol (in ginger), kratom, berberine, methylene blue, glyphosate… and there are many others. Anybody who has even remotely been paying attention the last few years should see that combinations of Pgp substrates and Pgp inhibitors have been pushed on the masses and next to nobody has warned people of the basic biology that is being exploited (I believe purposefully exploited) CYP3A4: The Poison Disassembler Cytochrome P450 3A4 (CYP3A4) is one of the most important enzymes in the Cytochrome P450 family, responsible for the metabolism (breaking down) of a vast array of toxins and drugs. Found predominantly in the liver and intestines, CYP3A4 metabolizes approximately 50% of all pharma drugs currently in use. CYP3A4 transforms lipophilic compounds into more water-soluble forms, facilitating their excretion from the body. This process is crucial for the elimination of various drugs, toxins, and endogenous substrates such as hormones. CYP3A4's broad substrate specificity allows it to handle a diverse range of chemical structures, making it a key player in the detoxification process. CYP3A4 activity can be limited by various factors, including genetic variables and interactions with other drugs called CYP3A4 inhibitors. These limitations can lead to differences in drug metabolism rates among individuals, affecting drug uptake levels and the risk of adverse effects. For instance, certain drugs, supplements and even foods can inhibit CYP3A4 activity, leading to increased plasma levels of co-administered drugs. Understanding these interactions is critical for optimizing drug therapy and avoiding potentially harmful drug-drug interactions. CYP3A4 Substrates and Inhibitors CYP3A4 substrates are compounds that the CYP3A4 enzyme metabolizes. A huge amount of commonly used medications and poisons are CYP3A4 substrates. By breaking down these substances, CYP3A4 works to minimize their accumulation to harmful levels in the body. CYP3A4 activity can be influenced by various factors, including genetic polymorphisms and interactions with other drugs. These variations can lead to differences in drug metabolism rates among individuals, affecting the risk of adverse effects. CYP3A4 inhibitors are substances that reduce the enzyme's activity, slowing the metabolism of its substrates. This can cause more drug uptake and for drugs to remain in the body longer, leading to increased toxicity. Examples of CYP3A4 inhibitors include grapefruit juice, certain antibiotics, methylene blue, caffeine, gingerol (in ginger), berberine, quercetin, milk thistle, elderberry, piperine (in black pepper), capsaicin (hot peppers), kratom, Ginkgo biloba, goldenseal, grape seed & CBD… and there are many others. Understanding these interactions is critical for avoiding potentially harmful drug-drug interactions. CYP3A4 substrates are drugs or toxins that are metabolized by CYP3A4 toxins are part of the detox process. Notable CYP3A4 substrates that are heavily pushed include: ivermectin, morphine, midazolam, remdesivir, HCQ, … and many others. Something like 50% of pharma drugs are CYP3A4 substrates. Implications For Pharmaceuticals & Supplements There are many potent over the counter Pgp inhibitors being pushed recklessly (I believe with bad intent). Likewise there are many toxic Pgp substrates that are being promoted in tandem. The combination of these can result in disaster. Similarly, numerous potent over-the-counter CYP3A4 inhibitors are being marketed irresponsibly. In addition, many hazardous CYP3A4 substrates are being promoted alongside them. This combination can lead to disastrous consequences. Nobody is being warned about the pharmacokinetics and the possibilities of severe drug interactions due to the inhibition of Pgp and CYP3A4. Always check the effects of what you are taking. I’ve seen so much foul play at this point that I don’t trust anything these poison pushers say anymore. I started actually researching all these weird supplements they are pushing and it screams that people are being deceived- tricked into consuming what amounts to terrible poison. They never show their work and they make the most vague ridiculous claims that upon closer inspection are clearly just invocations of dark psychology. My heart goes out to anyone who has fallen pray to the cacophony of awful medical advice on the internet and traditional media. I will debate anybody on the importance of Pgp and CYP3A4 and the harms of ivermectin - let’s set something up In future articles I will share more studies showing the increased accumulation of the substrates of Pgp and CYP3A4 when these detox pathways are inhibited, but to keep this article short and digestible, I will just refer you to prior articles I’ve written about Pgp and CYP3A4 with a focus on ivermectin which I have identified as a key tool for depopulation around the world: P-glycoprotein Deficiency (Genetic Or Drug Induced) & Increased Ivermectin Toxicity Pig Study Raises MAJOR Questions Of Dangers Of Combining Quercetin & Ivermectin Studies Find Quercetin & Natto K2 INHIBIT P-Glycoprotein; Will This Increase Ivermectin Toxicity Susceptibility?! Grapefruit's Irreversible Inactivation of Key Defense Against Toxic Effects Of Many Drugs (Ivermectin Binary Weapon) 2 Concerning Studies: CBD & THC Enact Potent P-Glycoprotein Inhibiting Effects, Raising Very Concerning Questions About Heightened Ivermectin Toxicity For Marijuana Users https://timtruth.substack.com/p/warning-your-detox-system-is-under-attack?utm_medium=web&triedRedirect=true

Dr Peter McCullough Recommends Dodgey Synthetic siRNA Jabs to Counter Effects of Dodgey Synthetic mRNA Jabs You're in great hands, health freedom movement! Not. Anthony Colpo The Medical Freedom Movement is full of suspicious characters. So suspicious you'd almost think the movement has been captured, or even commandeered from the outset, by the same people who brought us the 2020 blockbuster "The Great Culling: This Time, it’s Global!” There's Steve Kirsch, the DARPA teen protege and Rockefeller-linked buffoon famous for The Most Important Surveys You'll Ever Do!!, big money challenges he has no intention of fulfilling, surveillance state and CBDC technology, and aggressive promotion of the highly toxic, suicide-inducing SSRI fluvoxamine. There's Robert "Sly" Malone, the self-proclaimed inventor of "mRNA vaccine technology" who cries hard-done-by while swimming around in billion$ of grant money from the US Military (major enablers of the globalist death shot campaign), all while pretending claiming to be an injured vaxxx victim. There's Brett Weinstein, who helped propel Kirsch and Malone into stardom with his June 11, 2021 Darkhorse Podcast. In this creepy snippet from his Tucker Carlson interview, Weinstein gushes like a lovesick teen over mRNA technology. Such impassioned praise for a technology with a 30-year track record of failure, one that was successfully deployed to trigger accelerated death and disability around the world, is extremely curious for someone presenting as a health freedom fighter. There's Dr Ryan Cole who, at "the first Conversation on Covid" in Puerto Rico September 2021, emphatically emphasized “Covid is a clotting disease. Covid is a clotting disease. Covid is a clotting disease.” In case you didn't catch it the first three times, Cole reckons COVID is a clotting disease. Bollocks. COVID is regular cold, flu and pneumonia renamed and packaged as an uber-deadly new threat. They are not "clotting diseases" but respiratory ailments. What is a clotting disease is the common and now well-documented life-threatening thrombosis caused by the Unsafe and Ineffective gene therapies to treat the renamed COVID caused by the never-isolated Sars-Cov-2. Despite this clotting effect of the vaxxxines being well-established by September 2021, Cole preferred to blame the phenomenon on 'COVID.' With health freedom heroes like this, who needs villains? The “remarkable” San Juan “Covid Conversation” where health freedom spokespeople not chosen by you acted as if COVID was real and not a globalist psy-op. There's Dr Pierre Kory who, at the same star-studded gathering of pandemic shills, described COVID, the artist formerly known as Cold’n’Flu, as "the most complex and most violent disease that I have seen and the most difficult to treat in the ICU.” COVID: Once a simple cold you sat out with some hot tea, lemon juice and Vaporub, now the most complex and violent thug of a disease the world of medicine has ever seen! If the madicine gig ever stops working out for Kory, he should migrate to Australia and get a job as a SAPOL prosecutor - with such an unbridled capacity for egregious nonsense, he'd fit right in. Dr Pierre Kory, supposed member of the Health Freedom Movement, pushing the mask farce in uber-mainstream USA Today. The ‘Respectable’ Face of Pandemic and Gene Therapy Propaganda? Then there's the movement's smiling enigma, Dr Peter McCullough. Depending on who you listen to, McCullough is either a controlled opposition shill or the most sincere bloke you could ever meet. Compared to some of the other suspect characters who comprise the upper echelons of the health freedom movement, there's something disarming about McCullough. He doesn't have the grating motor mouth of Kirsch, nor the sinister gaze and evil gnome vibe of Malone. McCullough appears the polar opposite of Kirsch, who comes off like the tech-nerd version of your obnoxious, balding, know-it-all Uncle Barry. The guy who slurps, farts, belches at family gatherings and blames it on the dog, and challenges his nephews to wrestling matches while drunk then refuses to concede defeat when they repeatedly pin his fat hairy shoulders to the ground. McCullough seems more like your Uncle Ronald, the successful physician who arrives at family gatherings with your charmingly demure and well-liked Auntie Mary in his late model Jaguar. He doesn't act like a bogan, doesn't antagonize his nephews, and generally presents as a jovial, amicable, clean-living guy. But from behind McCullough's disarming facade there emanates some very dubious claims. I started to smell the pungent odour of pharma-sponsored allopathic bullpoop, extra-strength version, when McCullough claimed toxic statin drugs reduced the risk of dementia and Alzheimers Disease. Anyone who even pretends to care about health and medical freedom has no business praising toxic and ineffective garbage like cholesterol-lowering statins. To make his claim, McCullough had to ignore the substantial volume of clinical trial evidence showing both low cholesterol and cholesterol reduction via statins not only fail to prevent dementia and Alzheimers Disease, but often result in cognitive and neurological harms. Cholesterol is an integral component of your brain and nerve sheaths - claiming you can prevent cognitive and neurological decline by lowering cholesterol is like claiming your car will drive further and longer after you drain half the fuel from the tank. It is an inherently absurd and false thing to claim. McCullough, however, appears to have no issue with making inherently absurd and false claims. Because the RCT evidence wouldn't support his beloved statins, he instead based his untenable claims entirely upon a a 2022 meta-analysis of epidemiological studies by Italian researchers - two of whom have extensive ties to pharma companies, including cholesterol-lowering drug manufacturers like Pfizer, Merck, Amgen, Servier and Sanofi-Regeneron. Just brilliant. No matter how you wish to frame it, McCullough has benefited handsomely from the Big Pharma buy-an-opinion system in which ‘thought leaders’ are lavishly remunerated via speaking fees and ‘consulting’ arrangements. Since 2016, he has received over US $1.6 million in pharma largesse. While McCullough’s declared pharma funding did decline during the peak years of Covidiocy, this was replaced with a lucrative new career of worldwide COVID speaking engagements and supplement sales. For a guy who was allegedly ‘cancelled,’ McCullough sure got a lot of coverage. Others like Michael Yeadon, the former Pfizer executive with the pelotas to come out and identify the poison prick campaign for what it really was - a mass homicide event predicated upon a non-existent virus - curiously got nowhere near the exposure enjoyed by McCullough (and fellow pandemic shills like Kirsch and Malone). McCullough enthusiastically pimps what he calls “The McCullough Protocol.” This protocol includes his highly-priced “Spike Support” supplement (US $64.99 for a 60-day supply) which contains the following substances (bold emphases added): Nattokinase (“a proteolytic enzyme with fibrinolytic (anti-clotting) effects, that may maintain a healthy immune system”) Dandelion root (“may support cellular defense”) Selenium (“may help reduce stress, aiding the body repair itself and recover”) Black sativa extract (“may facilitate cellular repair”) Green tea extract (“may add defenses at the cellular level through scavenging for free radicals”) Irish sea moss (“is mineral-rich and may help rebuild damaged tissue and muscle”) It’s hard to think of a flimsier basis for promoting this motley array of ingredients as a vaxxx detox formula. Using the same rationale for Irish sea moss (“is mineral-rich and may help rebuild damaged tissue and muscle”), one might as well recommend a thick, juicy steak as a “Spike” detox. None of these ingredients have been shown in anything resembling a controlled scientific study to help ameliorate post-vaxxxine injuries. Green tea extract, in fact, has a solid track record of causing liver toxicity and is a great supplement to avoid the hell out of - a woefully ignored issue I discuss in detail here. McCullough’s Recent Spike in Dubious Gene Therapy Claims On April 19, 2023, McCullough posted a brief Substack about a paper by Matthew Halma, Jessica Rose and Theresa Lawrie titled "The Novelty of mRNA Viral Vaccines and Potential Harms: A Scoping Review." McCullough repeated the paper’s title as headline for his own article, adding his own byline of “mRNA Off to a Bad Start but Future may be Brighter.” McCullough’s article employed the same “we must keep an open mind, remain balanced, and not paint issues with a broad brush” shtick that he employed in his hopelessly wrong statin article. I agree it’s good to keep an open mind - but not so open that your brains fall out. “The Halma paper,” claims McCullough, “points out that safe mRNA products are possible.” Here’s what the paper actually said: “If harm can be exclusively and conclusively attributed to the spike protein, then it is possible that future mRNA vaccines expressing other antigens will be safe.” (Bold emphasis added) McCullough apparently couldn’t find it within himself to neither highlight nor discuss the statement that immediately followed: “If harms are attributable to the platform itself, then regardless of the toxicity, or lack thereof, of the antigen to be expressed, the platform may be inherently unsafe, pending modification.” (Bold emphasis added) The McCullough interpretation makes it sound as if safe and effective mRNA drugs are just around the corner; what Halma et al wrote is a far more heavily qualified statement that speculates a possible scenario in which the drugs could be considered safe. If that specific condition isn’t met, they posit that the technology may be inherently dangerous, period. It’s rather precious to bang on about the importance of maintaining a balanced viewpoint while leaving that key detail out… So is mRNA technology inherently flawed, or is it a brilliant idea that just needs a few wrinkles ironed out before it starts saving millions of lives? After more than 30 years of research, mRNA technology failed to produce even a single, safe effective drug that made it through mandatory Phase 3 trials and garnered a New Drug Approval. Heck, none of this junk ever made it past the Phase 2 stage. The only reason the COVID gene therapies made it to market was thanks to the monumental scam known as COVID, which allowed the criminals in charge to declare a sniffles ‘emergency’ and rush the drugs through via the “Emergency Use Authorization” Trojan horse. The aftermath of the gene therapy rollout has been untold misery, morbidity and a global excess death toll estimated, at last count, between 18 and 35 million people. The kind of body count that would make Genghis Khan and Chairman Mao proud. To say mRNA is “Off to a Bad Start” is a monumental understatement. To say the future for mRNA technology may be brighter when that technology is still under the control of the same GloboPedo-Pharma-Military-Industrial Complex that bought us the COVID psy-op and Poison Prick democide fills me with about as much optimism as a family of crackheads moving in next door. Using Dodgy Novel Gene Therapies to Counter the Effects of Dodgy Novel Gene Therapies McCullough isn’t letting up on the idea that highly problematic gene therapies could be just what the doctor ordered. Recently, he and colleagues Nicolas Hulscher and Diane Marotta published a preprint titled “Strategic Deactivation of mRNA COVID-19 Vaccines: New Applications for RIBOTACs and siRNA Therapy.” According to McCullough, Hulscher and Marotta: "The rapid development and authorization of mRNA vaccines by Pfizer-BioNTech (BNT162b2) and Moderna (mRNA-1273) in 2020 marked a significant milestone in human mRNA product application, overcoming previous obstacles such as mRNA instability and immunogenicity." Let's be perfectly clear: The rapid development and authorization of mRNA vaccines was not a triumph over previous developmental obstacles, it was the triumph of untold evil and corruption over the traditional regulatory requirements and safeguards that are supposed to protect us against dangerous and ineffective drugs. It was a triumph over the last remnants of mainstream investigative reporting, whose practitioners have been almost entirely replaced by unthinking morons who’ll do and write whatever their Globalist-controlled employers tell them to. It was confirmation that the self-aggrandizing West is not a conglomerate of freedom-protecting democracies, but a centrally-controlled constellation of financially and/or sexually compromised politicians, bureaucrats and billionaire deviants who hold us in sheer contempt and not only wish to remove our freedoms but our very existence on this planet. A few sentences later, McCullough et al effectively acknowledge that obstacle-crushing mRNA technology isn’t so great after all, when they write: “The stability of mRNA vaccines, their pervasive distribution, and the longevity of the encapsulated mRNA along with unlimited production of the damaging and potentially lethal Spike (S) protein call for strategies to mitigate potential adverse effects.” In plain English: “The mRNA gene therapies are dangerous garbage that have caused untold illness and death. We need an effective strategy to treat the poor bastards who have been injected with this poison.” It seems McCullough’s Spike Support is about as effective as a fishnet condom, because nowhere in their paper do he and his co-authors discuss it as a potential remedy. Instead, the strategies they devote their paper to are gene therapies known as “small interfering RNA” (siRNA) and “ribonuclease targeting chimeras” (RIBOTACs). Yep, more synthetic RNA technology. Because we all know how well that worked out last time. These Brave New World genetic concoctions, posit the authors, may help counter the damage done by the small interfering psychopaths and “useless eater”-targeting Chimeras behind The Great Culling (in Greek mythology, the Chimera was a monstrous fire-breathing hybrid creature). Except McCullough et al don’t acknowledge The Great Culling, because they continue to regurgitate the insulting fairy tale that COVID was a genuine pandemic caused by the never-isolated and non-existent Sars-Cov-2. Some examples of highly toxic Australian and American fire-breathing Chimeras and small interfering psychopaths. Silencers: Not Just for Guns Anymore At this point you’re probably asking, “What the heck are siRNA and RIBOTACs?” Discovered in 1998, small interfering RNAs, sometimes known as short interfering RNAs or silencing RNAs, are noncoding RNAs with important roles in gene regulation. The initially double-stranded siRNA gets into cells, becomes part of what is dubbed the RNA-Induced Silencing Complex (RISC), and is unwound to form single stranded siRNA. It's now fit for duty to go out and find a complementary mRNA. Once the single stranded siRNA binds to its target mRNA, it induces mRNA cleavage. No, it doesn't give the mRNA a breast lift; "cleavage" in the world of science means to cut something up. Don't ask me why they don't just say that outright. Anyways, once the mRNA is cut, it is recognized as abnormal by the cell. The cell goes into garbage disposal mode and further degrades the mRNA, which prevents translation of the mRNA into amino acids and then proteins. This is what the gene "silencing" and “interfering” terminology refers to. Like a mafia informant who gets brutally shanked and can no longer talk to the feds, siRNA-sliced mRNA can no longer translate its encoded instructions into functioning proteins. Sorry, that was a somewhat gory analogy. You’ll have to excuse me, I'm back in Australia at the moment, a gray, soulless Masonic pit of substance abuse and mental illness that is run, policed and adjudicated by some of GloboPedo's most enthusiastically obedient deviants. But I digress. And RIBOTACs? What the hell are they? RIBOTACs are a new, man-made class of small molecules that have the potential to target diverse types of RNAs. In 2018, Scripps Institute researchers reported they were able to modify a small molecule to recruit a nuclease to a specific gene transcript, triggering its destruction. In plain English: Researchers continue to develop ‘novel’ ways to screw around with your genes. McCullough and co-authors speculate that it might be possible to develop siRNA and RIBOTAC gene therapies that will act as little vaxxx mRNA-munching Pacmen (or Pacpersons/PacTheys/PacThems/ma vaffanculo to all you anally-retentive, pronoun-confused PC-types). Sounds great, but there’s a wee problem. Warn the authors, "despite their numerous advantages, substantial obstacles must be surmounted to effectively harness the power of siRNAs. Barriers to the successful implementation of siRNAs as a therapeutic intervention include their susceptibility to degradation by endogenous nucleases in serum, rapid renal clearance, activation of the innate immune system, plasma protein sequestration and entrapment by the reticuloendothelial system (RES), membrane impermeability, endosomal entrapment and off-target effects." In inglés normal: This strategy is purely speculative and theoretical. There is no actual evidence siRNA and RIBOTACs can effectively treat vaxxx injuries. In fact, when you look at the research closely, there is no solid evidence these technologies can treat anything effectively. To top it all off, these technologies presently have numerous shortcomings that preclude their efficacy and may lead to "off-target effects", which is a polite way of saying nasty-ass side effects. As proof this fledgling technology could actually work, McCullough and co offer two examples of current siRNA drugs. Yup, this stuff is already appearing on the market thanks to the industry-funded shonks at the FDA. The first is Inclisiran (trade name Leqvio®) which has received FDA approval as a treatment for the utter non-disease of hypercholesterolemia. It’s very important to ‘treat’ this non-disease effectively, because studies repeatedly show that in over-60s (the demographic in which most heart attacks occur), people with high cholesterol levels (including the so-called “bad” LDL) outlive those with low levels. Did you forget there was a Great Culling going on? The authors write “seven clinical trials have shown this siRNA therapy to be safe and well-tolerated for long-term administration.” It allegedly did this in conflict of interest-riddled studies conducted by original developer Alnylam Pharmaceuticals and Novartis, which licensed the rights to inclisiran from the former. Mean duration of this "long-term administration" was 2.8 years. During that time, inclirisan completely failed to show any tangible clinical benefit. Even the hopelessly corrupt FDA, which approved this junk, quietly admits “The effect of Leqvio on cardiovascular morbidity (suffering from a disease) and mortality (death) has not been determined.” In other words, taking inclirisan means an increased risk of adverse drug effects and no established health benefit. The only people guaranteed to benefit from this product are those who sell it, at a cost of US $6,500 a year. Every single one of the 11 authors of the post hoc analysis McCullough and co cite as evidence of inclirisan being Safe & Effective™ have lengthy links to Big Pharma. Five, in fact, were employees of Novartis at the time the analysis was performed. All the authors enjoyed financial largesse from an array of drug companies that included … take a big deep breath … Novartis, Boehringer Ingelheim, The Medicines Company, AstraZeneca, Amgen, Pfizer, DalCor Pharmaceuticals, Kowa, Corvidia Therapeutics, Esperion, Genentech, OMEICOS, Novo Nordisk, LIB Therapeutics, Daiichi-Sankyo, New Amsterdam Pharma, TenSixteen Bio, Berlin-Chemie, Bristol Myers Squibb, Sanofi, Singulex, Abbott, Roche Diagnostics, Dr Beckmann Pharma, Bayer, HLS, Merck/Merck Sharp and Dohme, Aegerion Pharmaceuticals, Cipla, Algorithm, Zuelling Pharma, Regeneron Pharmaceuticals, Eli Lilly, Cerenis Therapeutics, Akcea Therapeutics, Silence Therapeutics, Takeda, AbbVie and Resverlogix. In addition, one of the authors, Gregory G. Schwartz, is co-holder of a patent titled "Methods for Reducing Cardiovascular Risk." The patent revolves around the monoclonal antibody drug alirocumab which, like inclirisan, is a cholesterol-lowering drug whose mechanism of action is inhibition of a gene known as PCSK9. Like inclirisan, alirocumab does not save lives but comes with all the usual side effects attendant with cholesterol-lowering. Like inclirisan, alicrocumab is an out-and-out rort. When alirocumab and fellow useless PCSK9 inhibitor evolocumab hit the market in 2015, the retail cost was an absurd $14,000 per year. After many health insurance providers refused to pay for them, their price tag magically dropped by 60%. The amount of trust I have in such a conflict of interest-plagued panel of pharma-owned researchers when they claim the ineffective inclirisan is “safe and well-tolerated”? Absolute zero. Indeed, when you pull up the Supplementary Material and scroll down to page 23, you quickly learn why the all-cause mortality figure wasn’t included in the analysis’ main paper. During a mean exposure period of 2.8 years, 24 (0.7%) of inclirisan subjects died, compared to 3 (0.2%) of placebo subjects during an average exposure period of 1.35 years. When calculated in terms of "exposure-adjusted incidence rates," the death rates in the inclirisan and placebo groups were 0.24% and 0.11%, respectively. In other words, the "safe and well-tolerated" inclirisan more than doubled the death rate when compared to placebo. Patisiran Poppycock The other drug that McCullough et al put forward as an example of "safe and well-tolerated" siRNA treatment is patisiran (Onpattro®), which received FDA approval in 2018 for the treatment of polyneuropathy in patients with hereditary transthyretin-mediated amyloidosis. Just like inclirisan, the clinical evidence supposedly showing this drug to be hunky dory is the same old suspicious rot produced by the hopelessly flawed and demonstrably corrupt system in which drug companies conduct their own trials, get approval from their FDA buddies, pay ghost-writing outfits to draft the application and journal papers, while the rest of us are supposed to stick our heads up our keesters and pretend the drug really was shown to be safe and efficacious. The first published Phase 3 trial claiming safety and efficacy for patisiran appeared in the New World Order England Journal of Medicine in July 2018. In that paper, Adams et al reported the initial results of the “APOLLO” trial which, of course, was funded by Alnylam Pharmaceuticals. The study's lead author is David Adams, who has received "consulting honoraria from Isis, Alnylam, received fees from Pfizer for participating to symposium, is participating as principal investigator for trials with ISIS and Alnylam." We learn from the paper’s full text that “The first author and sponsor-employed authors prepared the first draft with editorial assistance provided by Adelphi Communications, under contract with Alnylam Pharmaceuticals.” Adelphi Communications is one of the countless “communication” outfits contracted by drug companies that do everything from oversee the recruitment and day-to-day operation of clinical trials to ghost-writing journal papers. Like most businesses in the private sector, the success of these companies revolves around pleasing their customers. The way to please drug companies is not by telling the truth about their dangerous and toxic products - it is by chopping and changing the data and writing up journal papers in a manner that portrays these products as safe and effective. A close read of the paper raises eyebrows. Partirisan, claim the authors, fared better than placebo on every outcome. The researchers also claim the incidence of “any adverse event” was identical between groups (97% each). They also claimed a lower rate of adverse cardiovascular events in the partirisan group. Hold that thought - we’ll return to it later. The most important outcome of all is overall mortality. The researchers report that seven patisiran patients (5%) and six placebo patients (8%) died during the 18-month trial. In 2020, the APOLLO researchers published another paper reporting on the 225 subjects randomized to receive either patisiran or placebo. In this paper, we are told 6 (4%) patisiran subjects died at 18 months, compared to 4 (5%) of placebo subjects. In 2022, researchers published results from the HELIOS-A trial. The randomized, Phase 3, open-label (non-blinded) study enrolled 164 patients; 42 received patisiran, 77 served as a control subjects, and 122 received Alnylam's new wonder siRNA concoction called vutrisiran. By way of remarkable coincidence, patisiran now displayed a near-identical death rate to placebo (7.1% vs 7.8%), and a marginally higher rate of serious and severe adverse events. By way of further remarkable coincidence, the new viturisan with its fresher patent protection produced a mere 1.6% death rate and a far lower rate of adverse events. Amazing. Or complete bollocks, depending on how schooled you are in the conduct of Big Pharma and the researchers it owns. In 2023, the results of the Alnylam-funded "APOLLO-B" trial were published. The main paper states that in the 12-month double-blind period, 4 deaths (2.2%) occurred in the patisiran group and 10 (5.6%) occurred in the placebo group. It then goes on to say that in the "safety analysis," there were five deaths (3%) in the patisiran group, and eight deaths (4%) in the placebo group. Seeking an explanation for these disparate figures, I opened up the trial's supplementary data. It was there I learned that in the patisiran group, four patients died during participation in the study and one died after withdrawing from the study. In the placebo group, four patients died during participation in the study and four died after study withdrawal. In other words, an equal number of patisiran and placebo subjects died while participating in the APOLLO-B trial. We also learn in the supplementary material that "Hospitalizations for any cause" were virtually identical in the two groups. In contrast to the original APOLLO trial, marginally higher rates of cardiac and cerebrovascular events occurred in the patisiran group. In summary, the only data claiming patisiran (and vutrisiran) benefits transthyretin amyloidosis patients just happens to come from trials conducted by the drug’s developer, Alnylam Pharmaceuticals, and the pharma-friendly researchers on its payroll. The suspect data from these trials fails to show any clear mortality benefit, which makes one wonder what the death data would’ve looked like had the trials been conducted by independent researchers with no vested interest in the results. Useless inclirisan and doubtful patisiran, it bears reiterating, are the two drugs put forward by McCullough et al as successful examples of siRNA technology. Lipid Nanopoison Now here’s the real cracker. Patisiran, which McCullough et al present as an example of a “safe and well-tolerated” siRNA product, contains lipid nanoparticles (LNPs). As do the most widely-deployed COVID gene therapies; namely, the Pfizer and Moderna kill shots. McCullough, you will recall, has made a lucrative name for himself as a staunch anti-mRNA vaxxx commentator. After reading the paper he co-authored with Hulscher and Marotta, I began to wonder if he suffered transient global amnesia (a known statin side effect) when drafting the paper. That paper lavishes praise upon LNPs and how they admirably transformed the useless and dangerous gene therapies that failed to garner approval into useless and dangerous gene therapies that garnered emergency use authorizations. Okay, that’s not exactly how they described it, but that’s exactly what happened. Their incessant praise of LNPs as an “adjuvant” that could help do the same for vaxxxMRNA-gobbling siRNA drugs is nothing short of mind-boggling. “Adjuvant,” by the way, is ScienceSpeak for a toxic substance disguised as an ingredient that allegedly improves the ‘immunogenicity’ of a vaccine. Anyone who believes injecting people with stuff like thimerosal, squalene or polyethylene glycol is truly going to benefit their immunity should probably start shopping around for a brain transplant. Way back in December 2020, within a week of the Pfizer kill shot being unleashed in the US, the LNP polyethylene glycol (PEG) was named as a likely cause of life-threatening anaphylaxis that occurred after injection with the democide drug. The issue, of course, has been swept under the carpet and PEG remains in the poison darts. As researchers recently pointed out, no studies have been undertaken to characterize the inflammatory reactions induced by the PEG-containing 'vaccine' platform. So the researchers tested a lipid nanoparticle formula made by Acuitas Therapeutics, who licenses its LNP technology to Pfizer. They gave mice the Acuitas poison formula, via intradermal and intramuscular injection, which "led to rapid and robust inflammatory responses, characterized by massive neutrophil infiltration, activation of diverse inflammatory pathways, and production of various inflammatory cytokines and chemokines." In Queen's English: This most questionable substance caused these most unfortunate mice an inordinate amount of physiological bother. In fact, when the mice were forced to ingest this junk via their snouts, they experienced an inordinate amount of death. "The same dose of LNP delivered intranasally," noted the researchers, "led to similar inflammatory responses in the lung and resulted in a high mortality rate." Coming soon: Intranasal vaccines with extra-strength LNP, brought to you by the friendly megalomaniacs at GloboPedo! In Summary For a guy who supposedly wants you to be healthy, Peter McCullough has a bizarre habit of recommending toxic pharma junk and awarding praise to dubious gene therapies that are light years away from proving themselves safe and effective. There are two possible reasons for this. One is that he is not very good at reading research and, like many doctors and cardiologists, is simply a brainwashed product of the pharma-owned and -operated medical system. The other possibility is that he is controlled opposition carefully packaged to look like your respectable Uncle Ronald. Instead of calling out the pandemic scam, he in fact helps pave the way for future shamdemics and shambolic gene therapy rollouts by proffering favourable and optimistic commentary on what has so far proven to be a truly nefarious and dangerous field of ‘science.’ For McCullough devotees offended that I dare mention the second possibility, I have this piece of advice: If you don’t want McCullough to be perceived as a possible controlled opposition figure, maybe ask him to stop acting like one. In the meantime, Mike Yeadon for President! Oh, wait, he’s from the UK. Damnit America, looks like you’re stuck with either Captain Warp Speed or Joe the Kiddy Fondler. As citizen of a country currently led by a vewy angwee* pwime minista who has been known to frequent Thai “Happy Ending” massage parlours to rewieve the stwess of fedwal powitics, I feel your pain. *PM Elmer Fudd is still vewy angwee dat wascawwy Austwalians voted ovawelmingwee against his pawly expwained “Voice” wefewendum. PM Fudd had a wot widing on dat wefewendum, and his land-gwabbing gwobawist masters are vewy upset dat it fayled. Share https://substack.com/home/post/p-145590321

Gene Therapy to Correct the Damage Done by Gene Therapy. What Could Possibly Go Wrong? Dr. Peter McCullough has been a courageous voice shouting out the horrifying dangers of mRNA jabs. Now he wants to play with your RNA to fix messing with your RNA. No, No, No, No!!!!! Rima E Laibow MD Something very, very wicked this way comes, supposedly to fix the last wicked thing that this way came. Share Dr. Peter McCullough, an early and widely sung hero in calling out the dangers of the Covid mRNA jabs (and a man who paid heavily in his academic and professional life for his bravery) recently (May 29, 2024) submitted a paper called “Strategic Deactivation of mRNA COVID-19 Vaccines: New Applications for RIBOTACs and siRNA Therapy”, The paper proposes that a special type of modified, engineered and altered micro RNA, also known as “siRNA”, to undo the damage caused by the unexpected persistence and surprisingly wide distribution of the damaging and potentially deadly mRNA of the gene therapy jabs licensed by the FDA and deployed by Pfizer and Moderna. That damage, the paper makes clear, was not fully tested for before approval of the shots, has been clinically observed but only partially studied and is neither, fully understood nor fully characterized. So, in simple terms, the use of lipid nanoparticles and structural modifications caused the foreign novel mRNA to spread, linger and negatively impact the recipient across a wide and very dangerous spectrum of impacts. Now, according to Dr. McCullough and his team, there is a wonderful new potential option: make two brand new kinds of modified, engineered and altered mRNA structures and destroyer molecules and stick them into the body and let them fix what the other poorly tested, irrationally dangerous bioweapons do to bodies. They, too, use lipid nanoparticles and enter the cells but, presumably, not the genetic material (really? Didn’t we hear that before? and didn’t it turn out to be, at the very least, an error? And, in many cases, a disastrous and/or fatal error?) Leave a comment On April 19, 2023, Dr. McCullough referenced in his substack, Courageous Discourse, a widely quoted scoping review of the mRNA vaccines called, “The Novelty of mRNA Viral Vaccines and Potential Harms: A Scoping Review”, In it, Drs. Halma, Rose and Lawrie looked at the possible positive uses of mRNA technology even though its first clinical deployment has been a biological disaster. Dr. McCullough introduced the article by noting, “The Halma paper points out that safe mRNA products are possible. For example, properly designed mRNA coding for normal proteins that are deficient or ones that are sufficiently humanized and not recognized by the body as foreign could indeed become part of the future pharmacopeia. But there is no doubt that the first use of mRNA on a mass, indiscriminate scale has been a disaster with the COVID-19 vaccine campaign.” On January 7, 2023, Sasha Latypova posted a YouTube video documenting the development of the COVID mRNA vaccines as bioweapons by the Department of Defense. Dr. McCullough has raised the same issues, suggesting that COVID-19 vaccines could be considered as part of a bioweapons program. Quick disclaimer: I am not a specialist in genetics, virology or immunology. I am a well-educated, iconoclastic critical thinker who has practiced outside the box, drug free psychiatry and medicine for 54 years. My clinical expertise is in understanding connections, root causes and their impacts and then finding ways to fix the basic problem(s) which caused the mis/mal/disfunction in the first place. That means that my mind works best looking at both the very big, interconnected web sort of picture and, at the same time, the minute, nuts and bolts mechanistic picture, too. So I am both a specialist and a generalist in various areas at the same time. But there is always a level of deep specialization that I simply have to take on faith. Highly technical statements about the manufacture and function of these molecules are not ones that I can evaluate with any level of precision so when the article states, for example, “Endogenous mRNA exits the nucleus to localize in the cytosol where the level of gene expression is mediated by rates of mRNA synthesis and degradation. The mRNA decay pathway is initiated via Pan2 Pan3 and Ccr4 Not complex mediated deadenylation. Subsequently, the mRNA can be processed through Xrn1 or exosome mediated degradation. That is, 5’ 3’ degradation occurs when the Lsm1 7/Pat 1 complex binds to the 3’ end and recruits the Dcp1 Dcp2 decapping complex thus exposing the 5’ end to Xrn1 enzymatic activity. Alternatively, 3’ 5’ degradation by the cytoplasmic exosome occurs without decapping. Based upon thousands of transcript decay rates, Yang et al. estimate that the median mRNA half-life in human cells is 10h. Interestingly, both gene function and sequence motifs are correlated with human mRNA decay rates” I cannot argue with, or agree with, the data and assertions presented here. But I can, as an intelligent and reasonably well-informed scientist and physician, question the premises being set forth here because it is remarkably simple: The use of the bioweapon jabs, developed to be bioweapons and therefore to damage and kill, which is, after all, what a bioweapon is supposed to do, when these bioweapons were misrepresented as vaccines, commonly understood to prevent damage and death, and authorized as the ONLY treatment or cure for the deadly pandemic threat has resulted in the most successful genocide in human history. Dr. Dennis Rancourt says that the deployment of these bioweapons has so far killed between 17-20 million people worldwide, at its most conservative number. Dr. James Thorp says that their deployment has, all things considered, resulted in the deaths of about a half a billion people and we are certainly not home yet when it comes to the final count of iatrogenocidal deaths (that is, doctor delivered deaths). The mRNA bioweapon, specifically, injected into the bodies of billions of people with inadequate testing for a health product, but perfectly adequate testing for a bioweapon, is killing us in ways both known, emerging and unknown. So, clearly, the antidote, the cure, the fix, for shooting a wildly toxic wild card gene therapy into the disposable population of the planet is to shoot another untested, unknown, cooked-up in a laboratory witches brew of gene therapy nightmares. What could possibly go wrong? If killing people is the goal, not much. I do not want to speculate on why Dr. McCullough would be pushing these ideas. The possibilities are very, very upsetting. I cannot believe that as knowledgeable and scientifically sophisticated doctor and researcher as Dr. McCullough would simply assume that another go-round of the world tragedy of a massive disaster in a syringe would somehow turn out just fine. I cannot believe that he would sincerely advocate for more of the toxin killing vast numbers of people to be injected because it MIGHT do more good than harm. I cannot believe that he would want to use a potentially helpful, or potentially disastrous genetic manipulation, complete with lipid nano particles and what sounds to me for all the world like a fully or semi-self assembling nano technology innovation on a population already dying from the use of pretty similar technology presented as a boon but which was - and is - really a bioweapon. Either I have missed something very basic and very important here or Dr. McCullough is working off another agenda than the one that he has positioned himself to be focused on. I am deeply distressed by this turn of events. Whichever the case is for Dr. McCullough, the fact is that the bioweapon is part of the strategy of the Death Machine currently arrayed to, quite literally, destroy humanity. That killing machine is a private club of Unelected Nobodies, the United Nations. And its “health” apparatus, the WHO, is a servomotor, not the driving force of the monster. Thus, in my opinion, as awful as the WHO is, and it really is quite terrible, it is merely a pimple on the ass of the monster. Instead of trying to empty the pus out of it, how about we kill the damn monster! Right now, there is a bill before the US Congress called the Disengaging Entirely From the UN Debacle Act of 2023 (HR 6645/ S 3428). And we need to pressure Congress so that they do not dare NOT pass it. I estimate it will take 10 million people riding their freedom mice using the Https://PreventGenocide2030.org website. It is quick, it is easy and it is essential. Please go there now, take the action and then make sure you have told everyone not only that you have taken the action, but how they can join the movement to make sure that the US and its allies leave the UIN completely. When you read the Legal Memo on that page, you will see that no country in the world actually has a valid treaty obligation with the UN Death Machine so what we are supporting with the US’ determination to exit the UN, is critically important in every country around the world. I have a simple mind. I do not understand how injecting pus and poison into a living thing is supposed to protect the living thing against some disease or other and actually help make you healthier. But as bad as vaccine practice is, this introduction of a novel mess-around-with-the-basic-operations-of-the-cells-and-genes to make things better that were caused by pretty much the same sort of malfeasance makes no sense to me in any way and scares the living daylights out of me. So, Dr. McCullough, what am I missing here? Please tell me I am wrong about your focus, your agenda and your intentions. You have been inspirational to me. I would hate to lose you. 1 2 The Novelty of mRNA Viral Vaccines and Potential Harms: A Scoping Review (substack.com) 3 The Novelty of mRNA Viral Vaccines and Potential Harms: A Scoping Review (substack.com) 4 Halma, M.T.J.; Rose, J.; Lawrie, T. The Novelty of mRNA Viral Vaccines and Potential Harms: A Scoping Review. J 2023, 6, 220-235. https://doi.org/10.3390/j6020017 https://substack.com/home/post/p-145884915

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More Proof mRNA Shots Edit Human Genome New Study Again Shows LINE-1 "Junk DNA" Does The Dirty Work Dr. Syed Haider Could the mRNA shots edit germline DNA? Honest scientists have always been worried about retrointegration of foreign mRNA from “vaccine” shots into our own cellular DNA. This fear should have been allayed by rigorous genotoxicity safety studies before the mRNA shots where rolled out, but those studies were waived by the Big Pharma controlled FDA (with the DoD behind the scenes pulling all the strings). Previous research showed that this could theoretically occur in a human liver cancer cell line inside a controlled laboratory setting utilizing our own bodies reverse transcriptase enzymes that are upregulated in cancer cells. Naysayers still argued that this situation was impossible or at least extremely unlikely to occur in our bodies. Unfortunately there is now further proof that this really does occur, either right away after vaccination, or if not, then it’s even more likely to occur once a vaccinated individual catches COVID-19, as long as vaccinal mRNA remains present in the body (so far we know it remains in circulation for weeks and in the lymph nodes for months - likely far longer, since all the studies had to be stopped, presumably due to lack of funding, or out of fear of creating unpublishable papers since the news wasn’t looking good). Thank you for reading Dr. Syed Haider. This post is public so feel free to share it. Share A new paper by Zhang et al, just released on Feb 13, 2023 proves that at artificially high concentrations in a lab setting, the SARS-CoV-2 virus can retrointegrate into our genome. Thankfully during natural infection such high levels of viral RNA do not typically occur, but … (you knew there had to be a “but”) … such high levels are induced by mRNA vaccination. So what the paper may actually prove in the roundabout way of most modern research (required for publication to ever happen in todays politically charged Big Pharma controlled publishing environment) is that the mRNA in the shots is in fact likely to retrointegrate into our cellular DNA. To dig into the details we need to start with a quick basic bio refresher: Understanding Genetics Nearly every cell in our bodies carries a full copy of our genetic code, or genome (the exceptions are red blood cells that have no genome, and sperm and egg cells that have half a genome since they are meant to combine with half of someone else's genome). Our genome is made up of individual genes encoded by DNA and bundled together into 46 chromosomes that are stored in a central compartment of our cells called the nucleus. In order to “read" the DNA code and convert it into the structure that makes up our bodies, it is first translated by a “reader” protein that writes it out into a new free floating molecule called mRNA for messenger RNA (the mRNA shots carry this messenger RNA, not modified RNA as some people think). The mRNA, unlike the DNA is not stuck inside the chromosome and it can exit the nucleus, going into the larger compartment called the cytoplasm of the cell, where its message is “read” and translated into an amino acid sequence that folds itself into a protein (either a body protein, or in the case of the shots the spike protein, or in the case of an RNA virus infection like SARS-CoV-2, all the proteins of the virus). Now going back to the nucleus: some of the individual DNA encoded genes can move around within their chromosomes and have therefore been described as "jumping genes" or technically speaking: transposable elements (TEs). Jumping genes! Some of these jumping genes (Class 1 TEs) use a copy and paste mechanism and others (Class 2 TEs), like the one in the cartoon depiction above, use a cut and paste mechanism. The Class 1 TEs (AKA retrotransposons) that use the copy and paste mechanism do so by translating their DNA into RNA and then converting the RNA back into DNA and inserting it somewhere else in the genome. The Class 1 TEs or retrotransposons, include within themselves the genetic code necessary to create their own protein enzyme to convert the DNA back into RNA, which is termed reverse transcriptase. Fun fact: retroviruses like HIV can be considered a special subtype of retrotransposon that can not only reinsert inside the same cell, but also travel to other cells “infecting” them and reverse transcribing into their genomes. In humans the only active jumping genes are from CLASS 1 TEs/retrotransposons and are called LINE-1 retrotransposons (LINE stands for Long Interspersed Nuclear Elements). LINE-1 retrotransposons were once considered to be junk DNA, they are usually inactivated, but can be turned on in aging cells, cancer cells, virus infected cells and in general in any cell subjected to significant stress. Junk DNA, which makes up 98.5% of our genome, is still little understood. It may help regulate the activity of the other 1.5% of the genome that does code for proteins, is likely involved in genome evolution, and has been implicated in disease states like cancer, autism and dozens of genetic diseases. So, what’s been shown in this new paper by Zhang et al, is that a lab clone of the SARS-CoV-2 virus, when present in very high levels, does turn on LINE-1, which means it also turns on the LINE-1 reverse transcriptase enzyme, which it then makes use of to reverse transcribe itself into our DNA. But even worse: genome sequencing found the viral genetic code transcribed into our DNA not only in cells where LINE-1 was actively turned on, or overexpressed above baseline, but even in cells where it was not. Is Sangamo's Gene-Editing Approach a Bust? | The Motley Fool Then, instead of studying the LNPs and spike protein RNA used in the shots, the researchers (who valued their careers) used a different mechanism of delivering low levels of nucleocapsid RNA into the cells in the lab to see if they also up regulated LINE-1 expression and were integrated into the cellular DNA. Turns out this handicapped experiment did not up regulate LINE-1, or get taken up in detectable quantities by healthy cells, though it did lead to genomic uptake in cells that already had LINE-1 upregulated - which again happens in aging cells, cancer cells, virus infected cells or simply in cells under stress (perhaps from LNP and spike protein induced inflammation?). The study authors addressed the discrepancy in retrointegration between the viral clone and their handicapped version of an mRNA shot by theorizing there were: "...several possible explanations for the differences in the levels of retrotransposition in infected and transfected cells: (i) The relative abundance of viral RNA is almost 2 orders of magnitude higher in infected than in transfected cells which would increase the probability of association with LINE1 proteins; (ii) virus infection, but not viral mRNA transfection, can induce endogenous LINE1 expression; (iii) multiple factors during SARS-CoV-2 infection can inhibit the antiviral/anti-retrotransposition function of stress granules (48–53), which could increase retrotransposition.” The first theory is the most concerning. Based on what we know from a 2020 study by Xie et al that showed the very high levels of intracellular viral RNA achieved by infectious clones, we can extrapolate that in the current study by Zhang et al the concentration of mRNA achieved by the SARS-CoV-2 viral clone was likely about 1000X greater than the low levels typically found during a natural infection. In fact the levels of mRNA in each cell achieved by the viral clone in the current study are actually far more likely to be achieved by transfection into cells of LNPs in the shots carrying spike protein mRNA than they are during a natural infection. Life finds a way. - Reaction GIFs So if the authors first theory is correct, that the difference in retrointegration rates simply depends on the intracellular concentration of foreign RNA, then retrointegration is very likely to occur due to exposure to mRNA in the shots, and it is likely to dramatically increase in case someone who has received the shot later becomes infected by the SARS-CoV-2 virus - since we know it upregulates LINE-1 expression, or if they are put under other stressors including the development of cancer, or by the stress of long COVID, chronic vaccine injury, autoimmune disease, autonomic dysfunction, POTS, MCAS, etc - all of which are also sadly enough triggered by the shot. This is less likely to happen in germ cell DNA - our sperm and egg cells - and lets hope it doesn’t happen, since we already know that the shots likely do transmit altered immunity from mother to child, if they also pass on the mRNA coding the spike protein itself then huge swaths of humanity may be forever genetically altered. Heres hoping the label “junk DNA” actually applies in this case… But, if you’ve been vaccinated: don’t worry! At mygotodoc we routinely reverse vaccine injuries and sincerely believe every disease has a cure. Fear is more likely to kill you than the shot (but do stop getting the boosters), and I mean that literally: fear destroys the immune system. A healthy immune system can keep any illness in check even if from a retrointegrated virus or viral mRNA fragment. There are a lot of unknowns, but don’t let that scare you. Take your health into your own hands and start making positive changes today. https://blog.mygotodoc.com/p/more-proof-mrna-shots-edit-human https://telegra.ph/More-Proof-mRNA-Shots-Edit-Human-Genome-09-17-2

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