More Proof mRNA Shots Edit Human Genome
New Study Again Shows LINE-1 "Junk DNA" Does The Dirty Work
Dr. Syed Haider
Could the mRNA shots edit germline DNA?
Honest scientists have always been worried about retrointegration of foreign mRNA from “vaccine” shots into our own cellular DNA.
This fear should have been allayed by rigorous genotoxicity safety studies before the mRNA shots where rolled out, but those studies were waived by the Big Pharma controlled FDA (with the DoD behind the scenes pulling all the strings).
Previous research showed that this could theoretically occur in a human liver cancer cell line inside a controlled laboratory setting utilizing our own bodies reverse transcriptase enzymes that are upregulated in cancer cells.
Naysayers still argued that this situation was impossible or at least extremely unlikely to occur in our bodies.
Unfortunately there is now further proof that this really does occur, either right away after vaccination, or if not, then it’s even more likely to occur once a vaccinated individual catches COVID-19, as long as vaccinal mRNA remains present in the body (so far we know it remains in circulation for weeks and in the lymph nodes for months - likely far longer, since all the studies had to be stopped, presumably due to lack of funding, or out of fear of creating unpublishable papers since the news wasn’t looking good).
Thank you for reading Dr. Syed Haider. This post is public so feel free to share it.
Share
A new paper by Zhang et al, just released on Feb 13, 2023 proves that at artificially high concentrations in a lab setting, the SARS-CoV-2 virus can retrointegrate into our genome.
Thankfully during natural infection such high levels of viral RNA do not typically occur, but … (you knew there had to be a “but”)
… such high levels are induced by mRNA vaccination.
So what the paper may actually prove in the roundabout way of most modern research (required for publication to ever happen in todays politically charged Big Pharma controlled publishing environment) is that the mRNA in the shots is in fact likely to retrointegrate into our cellular DNA.
To dig into the details we need to start with a quick basic bio refresher:
Understanding Genetics
Nearly every cell in our bodies carries a full copy of our genetic code, or genome (the exceptions are red blood cells that have no genome, and sperm and egg cells that have half a genome since they are meant to combine with half of someone else's genome).
Our genome is made up of individual genes encoded by DNA and bundled together into 46 chromosomes that are stored in a central compartment of our cells called the nucleus.
In order to “read" the DNA code and convert it into the structure that makes up our bodies, it is first translated by a “reader” protein that writes it out into a new free floating molecule called mRNA for messenger RNA (the mRNA shots carry this messenger RNA, not modified RNA as some people think).
The mRNA, unlike the DNA is not stuck inside the chromosome and it can exit the nucleus, going into the larger compartment called the cytoplasm of the cell, where its message is “read” and translated into an amino acid sequence that folds itself into a protein (either a body protein, or in the case of the shots the spike protein, or in the case of an RNA virus infection like SARS-CoV-2, all the proteins of the virus).
Now going back to the nucleus: some of the individual DNA encoded genes can move around within their chromosomes and have therefore been described as "jumping genes" or technically speaking: transposable elements (TEs).
Jumping genes!
Some of these jumping genes (Class 1 TEs) use a copy and paste mechanism and others (Class 2 TEs), like the one in the cartoon depiction above, use a cut and paste mechanism.
The Class 1 TEs (AKA retrotransposons) that use the copy and paste mechanism do so by translating their DNA into RNA and then converting the RNA back into DNA and inserting it somewhere else in the genome.
The Class 1 TEs or retrotransposons, include within themselves the genetic code necessary to create their own protein enzyme to convert the DNA back into RNA, which is termed reverse transcriptase.
Fun fact: retroviruses like HIV can be considered a special subtype of retrotransposon that can not only reinsert inside the same cell, but also travel to other cells “infecting” them and reverse transcribing into their genomes.
In humans the only active jumping genes are from CLASS 1 TEs/retrotransposons and are called LINE-1 retrotransposons (LINE stands for Long Interspersed Nuclear Elements).
LINE-1 retrotransposons were once considered to be junk DNA, they are usually inactivated, but can be turned on in aging cells, cancer cells, virus infected cells and in general in any cell subjected to significant stress.
Junk DNA, which makes up 98.5% of our genome, is still little understood. It may help regulate the activity of the other 1.5% of the genome that does code for proteins, is likely involved in genome evolution, and has been implicated in disease states like cancer, autism and dozens of genetic diseases.
So, what’s been shown in this new paper by Zhang et al, is that a lab clone of the SARS-CoV-2 virus, when present in very high levels, does turn on LINE-1, which means it also turns on the LINE-1 reverse transcriptase enzyme, which it then makes use of to reverse transcribe itself into our DNA.
But even worse: genome sequencing found the viral genetic code transcribed into our DNA not only in cells where LINE-1 was actively turned on, or overexpressed above baseline, but even in cells where it was not.
Is Sangamo's Gene-Editing Approach a Bust? | The Motley Fool
Then, instead of studying the LNPs and spike protein RNA used in the shots, the researchers (who valued their careers) used a different mechanism of delivering low levels of nucleocapsid RNA into the cells in the lab to see if they also up regulated LINE-1 expression and were integrated into the cellular DNA.
Turns out this handicapped experiment did not up regulate LINE-1, or get taken up in detectable quantities by healthy cells, though it did lead to genomic uptake in cells that already had LINE-1 upregulated - which again happens in aging cells, cancer cells, virus infected cells or simply in cells under stress (perhaps from LNP and spike protein induced inflammation?).
The study authors addressed the discrepancy in retrointegration between the viral clone and their handicapped version of an mRNA shot by theorizing there were:
"...several possible explanations for the differences in the levels of retrotransposition in infected and transfected cells: (i) The relative abundance of viral RNA is almost 2 orders of magnitude higher in infected than in transfected cells which would increase the probability of association with LINE1 proteins; (ii) virus infection, but not viral mRNA transfection, can induce endogenous LINE1 expression; (iii) multiple factors during SARS-CoV-2 infection can inhibit the antiviral/anti-retrotransposition function of stress granules (48–53), which could increase retrotransposition.”
The first theory is the most concerning.
Based on what we know from a 2020 study by Xie et al that showed the very high levels of intracellular viral RNA achieved by infectious clones, we can extrapolate that in the current study by Zhang et al the concentration of mRNA achieved by the SARS-CoV-2 viral clone was likely about 1000X greater than the low levels typically found during a natural infection.
In fact the levels of mRNA in each cell achieved by the viral clone in the current study are actually far more likely to be achieved by transfection into cells of LNPs in the shots carrying spike protein mRNA than they are during a natural infection.
Life finds a way. - Reaction GIFs
So if the authors first theory is correct, that the difference in retrointegration rates simply depends on the intracellular concentration of foreign RNA, then retrointegration is very likely to occur due to exposure to mRNA in the shots, and it is likely to dramatically increase in case someone who has received the shot later becomes infected by the SARS-CoV-2 virus - since we know it upregulates LINE-1 expression, or if they are put under other stressors including the development of cancer, or by the stress of long COVID, chronic vaccine injury, autoimmune disease, autonomic dysfunction, POTS, MCAS, etc - all of which are also sadly enough triggered by the shot.
This is less likely to happen in germ cell DNA - our sperm and egg cells - and lets hope it doesn’t happen, since we already know that the shots likely do transmit altered immunity from mother to child, if they also pass on the mRNA coding the spike protein itself then huge swaths of humanity may be forever genetically altered.
Heres hoping the label “junk DNA” actually applies in this case…
But, if you’ve been vaccinated: don’t worry!
At mygotodoc we routinely reverse vaccine injuries and sincerely believe every disease has a cure.
Fear is more likely to kill you than the shot (but do stop getting the boosters), and I mean that literally: fear destroys the immune system.
A healthy immune system can keep any illness in check even if from a retrointegrated virus or viral mRNA fragment.
There are a lot of unknowns, but don’t let that scare you. Take your health into your own hands and start making positive changes today.
https://blog.mygotodoc.com/p/more-proof-mrna-shots-edit-human https://telegra.ph/More-Proof-mRNA-Shots-Edit-Human-Genome-09-17-2More Proof mRNA Shots Edit Human Genome
New Study Again Shows LINE-1 "Junk DNA" Does The Dirty Work
Dr. Syed Haider
Could the mRNA shots edit germline DNA?
Honest scientists have always been worried about retrointegration of foreign mRNA from “vaccine” shots into our own cellular DNA.
This fear should have been allayed by rigorous genotoxicity safety studies before the mRNA shots where rolled out, but those studies were waived by the Big Pharma controlled FDA (with the DoD behind the scenes pulling all the strings).
Previous research showed that this could theoretically occur in a human liver cancer cell line inside a controlled laboratory setting utilizing our own bodies reverse transcriptase enzymes that are upregulated in cancer cells.
Naysayers still argued that this situation was impossible or at least extremely unlikely to occur in our bodies.
Unfortunately there is now further proof that this really does occur, either right away after vaccination, or if not, then it’s even more likely to occur once a vaccinated individual catches COVID-19, as long as vaccinal mRNA remains present in the body (so far we know it remains in circulation for weeks and in the lymph nodes for months - likely far longer, since all the studies had to be stopped, presumably due to lack of funding, or out of fear of creating unpublishable papers since the news wasn’t looking good).
Thank you for reading Dr. Syed Haider. This post is public so feel free to share it.
Share
A new paper by Zhang et al, just released on Feb 13, 2023 proves that at artificially high concentrations in a lab setting, the SARS-CoV-2 virus can retrointegrate into our genome.
Thankfully during natural infection such high levels of viral RNA do not typically occur, but … (you knew there had to be a “but”)
… such high levels are induced by mRNA vaccination.
So what the paper may actually prove in the roundabout way of most modern research (required for publication to ever happen in todays politically charged Big Pharma controlled publishing environment) is that the mRNA in the shots is in fact likely to retrointegrate into our cellular DNA.
To dig into the details we need to start with a quick basic bio refresher:
Understanding Genetics
Nearly every cell in our bodies carries a full copy of our genetic code, or genome (the exceptions are red blood cells that have no genome, and sperm and egg cells that have half a genome since they are meant to combine with half of someone else's genome).
Our genome is made up of individual genes encoded by DNA and bundled together into 46 chromosomes that are stored in a central compartment of our cells called the nucleus.
In order to “read" the DNA code and convert it into the structure that makes up our bodies, it is first translated by a “reader” protein that writes it out into a new free floating molecule called mRNA for messenger RNA (the mRNA shots carry this messenger RNA, not modified RNA as some people think).
The mRNA, unlike the DNA is not stuck inside the chromosome and it can exit the nucleus, going into the larger compartment called the cytoplasm of the cell, where its message is “read” and translated into an amino acid sequence that folds itself into a protein (either a body protein, or in the case of the shots the spike protein, or in the case of an RNA virus infection like SARS-CoV-2, all the proteins of the virus).
Now going back to the nucleus: some of the individual DNA encoded genes can move around within their chromosomes and have therefore been described as "jumping genes" or technically speaking: transposable elements (TEs).
Jumping genes!
Some of these jumping genes (Class 1 TEs) use a copy and paste mechanism and others (Class 2 TEs), like the one in the cartoon depiction above, use a cut and paste mechanism.
The Class 1 TEs (AKA retrotransposons) that use the copy and paste mechanism do so by translating their DNA into RNA and then converting the RNA back into DNA and inserting it somewhere else in the genome.
The Class 1 TEs or retrotransposons, include within themselves the genetic code necessary to create their own protein enzyme to convert the DNA back into RNA, which is termed reverse transcriptase.
Fun fact: retroviruses like HIV can be considered a special subtype of retrotransposon that can not only reinsert inside the same cell, but also travel to other cells “infecting” them and reverse transcribing into their genomes.
In humans the only active jumping genes are from CLASS 1 TEs/retrotransposons and are called LINE-1 retrotransposons (LINE stands for Long Interspersed Nuclear Elements).
LINE-1 retrotransposons were once considered to be junk DNA, they are usually inactivated, but can be turned on in aging cells, cancer cells, virus infected cells and in general in any cell subjected to significant stress.
Junk DNA, which makes up 98.5% of our genome, is still little understood. It may help regulate the activity of the other 1.5% of the genome that does code for proteins, is likely involved in genome evolution, and has been implicated in disease states like cancer, autism and dozens of genetic diseases.
So, what’s been shown in this new paper by Zhang et al, is that a lab clone of the SARS-CoV-2 virus, when present in very high levels, does turn on LINE-1, which means it also turns on the LINE-1 reverse transcriptase enzyme, which it then makes use of to reverse transcribe itself into our DNA.
But even worse: genome sequencing found the viral genetic code transcribed into our DNA not only in cells where LINE-1 was actively turned on, or overexpressed above baseline, but even in cells where it was not.
Is Sangamo's Gene-Editing Approach a Bust? | The Motley Fool
Then, instead of studying the LNPs and spike protein RNA used in the shots, the researchers (who valued their careers) used a different mechanism of delivering low levels of nucleocapsid RNA into the cells in the lab to see if they also up regulated LINE-1 expression and were integrated into the cellular DNA.
Turns out this handicapped experiment did not up regulate LINE-1, or get taken up in detectable quantities by healthy cells, though it did lead to genomic uptake in cells that already had LINE-1 upregulated - which again happens in aging cells, cancer cells, virus infected cells or simply in cells under stress (perhaps from LNP and spike protein induced inflammation?).
The study authors addressed the discrepancy in retrointegration between the viral clone and their handicapped version of an mRNA shot by theorizing there were:
"...several possible explanations for the differences in the levels of retrotransposition in infected and transfected cells: (i) The relative abundance of viral RNA is almost 2 orders of magnitude higher in infected than in transfected cells which would increase the probability of association with LINE1 proteins; (ii) virus infection, but not viral mRNA transfection, can induce endogenous LINE1 expression; (iii) multiple factors during SARS-CoV-2 infection can inhibit the antiviral/anti-retrotransposition function of stress granules (48–53), which could increase retrotransposition.”
The first theory is the most concerning.
Based on what we know from a 2020 study by Xie et al that showed the very high levels of intracellular viral RNA achieved by infectious clones, we can extrapolate that in the current study by Zhang et al the concentration of mRNA achieved by the SARS-CoV-2 viral clone was likely about 1000X greater than the low levels typically found during a natural infection.
In fact the levels of mRNA in each cell achieved by the viral clone in the current study are actually far more likely to be achieved by transfection into cells of LNPs in the shots carrying spike protein mRNA than they are during a natural infection.
Life finds a way. - Reaction GIFs
So if the authors first theory is correct, that the difference in retrointegration rates simply depends on the intracellular concentration of foreign RNA, then retrointegration is very likely to occur due to exposure to mRNA in the shots, and it is likely to dramatically increase in case someone who has received the shot later becomes infected by the SARS-CoV-2 virus - since we know it upregulates LINE-1 expression, or if they are put under other stressors including the development of cancer, or by the stress of long COVID, chronic vaccine injury, autoimmune disease, autonomic dysfunction, POTS, MCAS, etc - all of which are also sadly enough triggered by the shot.
This is less likely to happen in germ cell DNA - our sperm and egg cells - and lets hope it doesn’t happen, since we already know that the shots likely do transmit altered immunity from mother to child, if they also pass on the mRNA coding the spike protein itself then huge swaths of humanity may be forever genetically altered.
Heres hoping the label “junk DNA” actually applies in this case…
But, if you’ve been vaccinated: don’t worry!
At mygotodoc we routinely reverse vaccine injuries and sincerely believe every disease has a cure.
Fear is more likely to kill you than the shot (but do stop getting the boosters), and I mean that literally: fear destroys the immune system.
A healthy immune system can keep any illness in check even if from a retrointegrated virus or viral mRNA fragment.
There are a lot of unknowns, but don’t let that scare you. Take your health into your own hands and start making positive changes today.
https://blog.mygotodoc.com/p/more-proof-mrna-shots-edit-human
https://telegra.ph/More-Proof-mRNA-Shots-Edit-Human-Genome-09-17-2
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